concept

CERAMIDE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CERAMIDE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

274Connections
4Hypotheses
1Analyses
50Outgoing
50Incoming
1Experiments
1Debates

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💡 Concept Info
NameCERAMIDE
Key Genes/ProteinsACSL4, AKT, ALPHA-SYNUCLEIN, ALZHEIMER, AMYLOID, APOE
Related DiseasesAGING, Alzheimer'S Disease, ALZHEIMER'S DISEASE

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Ceramide Signaling Pathway in Neurodegeneration

mechanism · 2973 words

Pathway Diagram

flowchart TD
    N0["CERAMIDE"]
    N1["SMPD1"]
    N1 -->|"produces"| N0
    N2["APOE"]
    N2 -->|"treats"| N0
    N3["NEUROINFLAMMATION"]
    N0 -->|"activates"| N3
    N4["ENDOPLASMIC RETICULUM"]
    N0 -->|"regulates"| N4
    N5["TAU"]
    N0 -->|"activates"| N5
    N6["MITOCHONDRIAL DYSFUNCTION"]
    N0 -->|"causes"| N6
    N7["APP"]
    N0 -->|"inhibits"| N7
    N8["AXONAL TRANSPORT"]
    N0 -->|"inhibits"| N8
    N9["INSULIN RESISTANCE"]
    N0 -->|"activates"| N9

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    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef drug fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
    classDef cell_type fill:#2a1a2a,stroke:#ab47bc,color:#e0e0e0
    classDef phenotype fill:#2a2a1a,stroke:#ffa726,color:#e0e0e0
    classDef process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
    classDef biological_process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
    classDef concept fill:#1a1a2a,stroke:#7986cb,color:#e0e0e0
    classDef entity fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef therapeutic fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
    classDef index fill:#1a1a2a,stroke:#7986cb,color:#e0e0e0
    class N0 concept
    class N1 gene
    class N2 gene
    class N3 phenotype
    class N5 protein
    class N6 phenotype
    class N7 gene
    class N8 phenotype
    class N9 phenotype

Outgoing (158)

TargetRelationTypeStr
Neuronal Apoptosispromotesprocess0.90
SMS1substrate_ofenzyme0.90
tau phosphorylationpromotesprocess0.90
Amyloid-Βcontributes_tocompound0.90
Cerebral Ischemia/Reperfusion Injuryassociated_withdisease0.90

Incoming (116)

SourceRelationTypeStr
Myriocinassociated_withdrug0.95
Myriocindownregulatesdrug0.90
SPTcatalyzesenzyme0.90
CERS2associated_withgene0.90
39929585is involved inpaper0.90

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
SMPD1 (Acid Sphingomyelinase) Inhibition for Ceramide Reduct 0.732 neurodegeneration How do sphingomyelin/ceramide ratios spe
Glucosylceramide Accumulation from GCase Deficiency Disrupts 0.700 neurodegeneration -
Glucosylceramide accumulation nucleates alpha-synuclein aggr 0.525 Parkinson's disease GBA-Synuclein Loop Therapeutics for PD
Glucosylceramide-mediated feedback loop drives GBA-synuclein 0.380 Parkinson's disease GBA-Synuclein Loop: Therapeutic Strategi

Mentioning Analyses (1)

Scientific analyses that reference this entity

Metabolomic signatures of neurodegeneration and energy metabolism dysfunction

neurodegeneration | 2026-04-04 | 0 hypotheses

Experiments (1)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
Pain has been frequently reported as an initial symptom and the most t genetic_association Parkinson's disease 0.500 0.00 human extracted N/A

Related Papers (9)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
Pathogenic Variants and Olipudase Alfa Treatment of Patients With Acid Sphingomy [PMID:41692468] ["Hsu-Heng Lin", "Hui-An Chen", "Shyh-Je Molecular genetics & genom 2026 0
Multi-omics analysis identifies SMPD1 as a key contributor in sphingolipid pathw [PMID:41428198] ["Aron Park", "Baeki E Kang", "Eun-Ju Ji Genes & genomics 2026 0
A multi-dimensional bioinformatic dissection of the molecular mechanisms in high [PMID:41191606] Yu X MD, Lei J MSc, Du X MSc, He Y MSc, Int J Surg 2026 0
Plasma metabolites may inhibit childhood obesity by regulating ferroptosis throu [PMID:41249848] Wang JG, Pan XH, Li Y Int J Obes (Lond) 2026 0
Multi-omics analysis identifies SMPD1 as a key contributor in sphingolipid pathw [PMID:41428198] Park A, Kang BE, Jin EJ, Kim HJ, Lee CW Genes Genomics 2026 0
AXL Promotes Ischemic Myelin Repair Through Alleviating Myelin Debris Deposition [PMID:41524160] Jia J, Gan Y, Li J, Li L, Meng H et al. Adv Sci (Weinh) 2026 0
Pathogenic Variants and Olipudase Alfa Treatment of Patients With Acid Sphingomy [PMID:41692468] Lin HH, Chen HA, Lin SJ, Hsu RH, Lee NC Mol Genet Genomic Med 2026 0
AXL Promotes Ischemic Myelin Repair Through Alleviating Myelin Debris Deposition [PMID:41524160] Jia J, Gan Y, Li J, Li L, Meng H, Sun M, Advanced science (Weinheim, Ba 2026 0
A multi-dimensional bioinformatic dissection of the molecular mechanisms in high [PMID:41191606] Yu X, Lei J, Du X, He Y, Peng W, Yang R, International journal of surge 2026 0

Debates (1)

Multi-agent debates referencing this entity

How do metabolomic alterations in glucose metabolism, mitochondrial function, an

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

Related Research

Hypotheses and analyses mentioning CERAMIDE in their description or question text

No additional research found