Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GPR132: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
GPR132 (G2A) is a proton-sensing G protein-coupled receptor that detects acidic extracellular pH, lactate, and lipid mediators. It plays critical roles in metabolic stress response, immune cell regulation, cancer metastasis, and has emerging implications for neurodegeneration and neuroinflammation
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| Gene Symbol | GPR132 |
| Full Name | G protein-coupled receptor 132 |
| Chromosome | 14q24.2 |
| Protein Family | Proton-sensing GPCRs (GPR4 family) |
| Protein Type | Receptor |
| Function | is a member of the proton-sensing GPCR family that functions as a cellular sensor of acidification. |
| Primary Expression | various tissues including brain, immune cells, and metabolic organs |
| Amino Acids | 380 aa |
| Pathways | NF-κB |
| UniProt ID | Q9Y5S2 |
| NCBI Gene ID | 29933 |
| Ensembl ID | ENSG00000168214 |
| OMIM | 616087 |
| GeneCards | GPR132 |
| Human Protein Atlas | GPR132 |
| Associated Diseases | neurodegeneration |
| Interactions | AGING, AND, LDL, SRC |
| KG Connections | 9 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["GPR132"]
N1["Aging"]
N0 -->|"activates"| N1
N2["Diabetes"]
N0 -->|"activates"| N2
N3["Atherosclerosis"]
N0 -->|"activates"| N3
N4["Senescence"]
N0 -->|"activates"| N4
N5["LDL"]
N0 -->|"activates"| N5
N6["Glycolysis"]
N0 -->|"activates"| N6
N7["SRC"]
N7 -->|"activates"| N0
N8["AND"]
N8 -->|"activates"| N0
N9["AGING"]
N9 -->|"activates"| N0
N10["neurodegeneration"]
N0 -->|"implicated in"| N10
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N1 disease
class N2 disease
class N3 disease
class N4 disease
class N5 gene
class N6 pathway
class N7 gene
class N8 gene
class N9 gene| Target | Relation | Type | Str |
|---|---|---|---|
| Aging | activates | disease | 0.65 |
| Diabetes | activates | disease | 0.65 |
| Atherosclerosis | activates | disease | 0.65 |
| Senescence | activates | disease | 0.65 |
| LDL | activates | gene | 0.60 |
| Glycolysis | activates | pathway | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning GPR132 in their description or question text
No additional research found