protein 1,288 words KG: LDLRECEPTOR
Contents

LDL Receptor Protein

🔬 Protein Info
Gene SymbolLDLRECEPTOR
Full NameLDL Receptor
Protein TypeProtein
Functionis a cell surface receptor essential for cholesterol homeostasis.
Primary Expressionepithelial cells
Amino Acids40 aa
UniProt IDSearch UniProt
GeneCardsLDLRECEPTOR
Human Protein AtlasLDLRECEPTOR
Ligand-binding repeats (LA repeats)Seven repeats of approximately 40 amino acids each, containing negatively charged amino acids that interact with positively charged residues on apolipoproteins
EGF-like domainsThree epidermal growth factor precursor homology domains
O-linked sugar domainA region with O-linked glycosylation
Transmembrane domainSingle pass transmembrane helix (22 amino acids)
Cytoplasmic tailContains an NPXY internalization signal and a di-leucine sorting motif
LDLRClassic LDL receptor
Associated Diseasesneurodegeneration
DatabasesGeneCardsNCBI GeneHPASTRING

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Related Hypotheses (18)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
APOE Isoform Conversion Therapy
Score: 0.72
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71
LRP1-Dependent Tau Uptake Disruption
Score: 0.60
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.86
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
Membrane Cholesterol Gradient Modulators
Score: 0.71
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (10)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (3)

Myricanol treatment in HFD-induced hyperlipidemic C57BL/6J m
validation · proposed · Score: 0.95
ox-LDL treatment of RAW264.7 macrophages
exploratory · proposed · Score: 0.85
Validation of hub genes in ox-LDL treated RAW264.7 macrophag
exploratory · proposed · Score: 0.80

See Also (15)

RNA-Targeted Therapies in Neurodegeneration
mechanism · Pages share 6 hypotheses
LX1001 Phase 1/2 Trial (NCT03634007) - Gene Therapy for
clinical · Pages share 6 hypotheses
Endosomal-Lysosomal Pathway in Neurodegeneration
mechanism · Pages share 6 hypotheses
Cerebral Amyloid Angiopathy Pathway in Neurodegeneratio
mechanism · Pages share 6 hypotheses
PPAR Signaling Pathway in Neurodegeneration
mechanism · Pages share 6 hypotheses

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