| Gene Symbol | LRP5 |
| Aliases | Page for LRP5 Protein |
| Protein Type | Receptor |
| Function | Wnt Binding: LRP5 binds Wnt ligands (Wnt1, Wnt3, Wnt3a) in conjunction with Frizzled receptors |
| Primary Expression | the central nervous system where it plays important roles in neuronal development, synaptic plasticity, and cognitive function[@gong2001] |
| Molecular Weight | 179 kDa |
| Amino Acids | 1615 aa |
| Pathways | Wnt, Wnt signaling, Wnt Signaling |
| UniProt ID | [O75177](https://www.uniprot.org/uniprot/O75177) |
| Ensembl ID | ENSG00000162337 |
| GeneCards | LRP5 |
| Human Protein Atlas | LRP5 |
| Single transmembrane helix | Spans the cell membrane, anchoring the receptor complex. |
| C-terminal cytoplasmic tail | Contains PPXY motifs that interact with β-catenin destruction complex components and facilitate downstream signaling. |
| Synaptic plasticity | Regulates NMDA receptor trafficking and long-term potentiation (LTP) |
| Associated Diseases | Aging, Als, Atherosclerosis, Autosomal Dominant Polycystic Kidney Diseases, Autosomal Dominant Polycystic Liver Diseases |
| Interactions | Actin, AMYLOID, APOE, APOE3, APOE4, App |
| KG Connections | 119 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!
No comments yet. Be the first to comment!