gene

KCNE1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KCNE1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1Connections

0Hypotheses

0Analyses

0Outgoing

1Incoming

0Experiments

0Debates

Summary

Page for KCNE1

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🧬 Gene Info

Gene Symbol	KCNE1
Full Name	Potassium Voltage-Gated Channel Subfamily E Member 1
Chromosome	21q22.12
Function	KCNE1 encodes MinK (minimal potassium channel subunit), a 129-amino acid single-pass membrane protein that co-assembles with Kv channel alpha subunits (particularly KCNQ1) to form functional channels.
Molecular Weight	14.3 kDa
Amino Acids	129 aa
UniProt ID	P15382
NCBI Gene ID	3750
Ensembl ID	ENSG00000180509
OMIM	176267
GeneCards	KCNE1
Human Protein Atlas	KCNE1
Transmembrane Domain	Single α-helix spanning the membrane
N-terminus	Extracellular, glycosylated
C-terminus	Intracellular, involved in channel modulation
Associated Diseases	neurodegeneration
Interactions	KCNQ1
KG Connections	1 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: KCNE1 — AlphaFold P15382 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

KCNE1 Protein

protein · 709 words

→

KCNE1

gene · 689 words

→

Pathway Diagram

flowchart TD
    N0["KCNE1"]
    N1["KCNQ1"]
    N1 -->|"interacts with"| N0
    N2["neurodegeneration"]
    N0 -->|"implicated in"| N2

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 gene

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (1)

Source	Relation	Type	Str
KCNQ1	interacts_with	gene	0.90

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning KCNE1 in their description or question text

No additional research found