gene

KCNE3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KCNE3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

8Connections

0Hypotheses

0Analyses

6Outgoing

2Incoming

0Experiments

0Debates

No summary available yet.

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🧬 Gene Info

Gene Symbol	KCNE3
Aliases	MinK-related peptide 3
Chromosome	11p15.5
Protein Type	Gene
Function	is a critical regulatory subunit that modulates the function of various voltage-gated potassium (Kv) channels.
Primary Expression	both cardiac and neuronal tissues, where it plays crucial roles in regulating excitability
Molecular Weight	19 kDa
Amino Acids	179 aa
Exons	3
UniProt ID	Q9NP86
NCBI Gene ID	10088
GeneCards	KCNE3
Human Protein Atlas	KCNE3
Altered gating kinetics	Changed activation and inactivation rates
Shifted voltage dependence	Modified voltage sensitivity of channel activation
Associated Diseases	neurodegeneration
Interactions	KCNQ1
KG Connections	8 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: KCNE3 — AlphaFold Q9NP86 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

KCNE3 (Potassium Voltage-Gated Channel Subfamily E Regulatory Subunit 3)

gene · 1987 words

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KCNE3 Protein

protein · 822 words

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Pathway Diagram

graph TD
    KCNE3["KCNE3"]
    KCNQ1["KCNQ1"]
    KCNE3 -->|"modulates"| KCNQ1
    KCNE3 -->|"regulates"| KCNQ1
    S1_segment["S1 segment"]
    KCNE3 -->|"binds"| S1_segment
    KCNE3 -->|"activates"| KCNQ1
    R228["R228"]
    KCNE3 -->|"binds"| R228
    KCND3["KCND3"]
    KCNE3 -->|"binds"| KCND3
    neurodegeneration["neurodegeneration"]
    KCNE3 -->|"implicated in"| neurodegeneration
    KCNQ1 -->|"binds"| KCNE3
    style KCNE3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (6)

Target	Relation	Type	Str
KCNQ1	modulates	gene	0.80
KCNQ1	regulates	gene	0.80
S1 segment	binds	protein	0.80
KCNQ1	activates	gene	0.80
R228	binds	protein	0.70
KCND3	binds	gene	0.70

Incoming (2)

Source	Relation	Type	Str
genes-kcne3	linked_to	wiki_page	1.00
KCNQ1	binds	gene	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning KCNE3 in their description or question text

No additional research found