concept

ASK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ASK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

111Connections

0Hypotheses

0Analyses

50Outgoing

16Incoming

0Experiments

0Debates

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💡 Concept Info

Name	ASK1
Key Genes/Proteins	AKT, amyloid_beta, APP, ASC, ATF3
Related Diseases	ALS, Alzheimer's disease, Alzheimer's Disease, ALZHEIMER'S_DISEASE, amyotrophic lateral sclerosis
Related Pathways	apoptosis pathway

Pathway Diagram

graph TD
    ASK1["ASK1"]
    ASK1 -->|"regulates"| Neuronal_Apoptosis["Neuronal Apoptosis"]
    ASK1 -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    ASK1 -->|"contributes to"| Alzheimer_s_Disease["Alzheimer's Disease"]
    ASK1 -->|"contributes to"| Parkinson_s_Disease["Parkinson's Disease"]
    ASK1 -->|"contributes to"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    ASK1 -->|"contributes to"| Huntington_s_Disease["Huntington's Disease"]
    Oxidative_Stress["Oxidative Stress"] -->|"activates"| ASK1
    Endoplasmic_Reticulum_Stress["Endoplasmic Reticulum Stress"] -->|"activates"| ASK1
    SOD1["SOD1"] -->|"activates"| ASK1
    HTT["HTT"] -->|"activates"| ASK1
    SNCA["SNCA"] -->|"activates"| ASK1
    ER_stress["ER_stress"] -->|"activates"| ASK1
    oxidative_stress["oxidative_stress"] -->|"activates"| ASK1

Outgoing (95)

Target	Relation	Type	Str
NEUROINFLAMMATION	regulates	process	0.95
APOPTOSIS	regulates	process	0.95
Neuroinflammation	regulates	process	0.95
Neuronal Apoptosis	regulates	process	0.95
NEURODEGENERATION	contributes_to	process	0.95
Neuronal Apoptosis	activates	process	0.95
Neuroinflammation	modulates	process	0.92
Neuroinflammation	mediates	process	0.90
Amyotrophic Lateral Sclerosis	involved_in	disease	0.90
ALZHEIMER'S_DISEASE	associated_with	disease	0.90
PARKINSON'S_DISEASE	associated_with	disease	0.90
ALS	associated_with	disease	0.90
Alzheimer's Disease	associated_with	disease	0.90
Parkinson's Disease	associated_with	disease	0.90
Amyotrophic Lateral Sclerosis	contributes_to	disease	0.90
Huntington's Disease	associated_with	disease	0.90
MKK7	phosphorylates	protein	0.85
Multiple Sclerosis	associated_with	disease	0.85
Tau Hyperphosphorylation	mediates	process	0.85
Motor Neuron Degeneration	causes	phenotype	0.85
Tau Hyperphosphorylation	causes	process	0.85
TAU	phosphorylates	protein	0.85
NEURON	mediates	cell_type	0.85
Oxidative Stress	associated_with	process	0.85
INFLAMMATION	modulates	process	0.85
Amyloid-Beta-Induced Neurotoxicity	mediates	process	0.85
Dopaminergic Neuron Degeneration	causes	process	0.85
Amyloid-Beta-Induced Neurotoxicity	involved_in	process	0.85
Motor Neuron Degeneration	associated_with	process	0.85
neuronal injury	contributes_to	phenotype	0.80
dopaminergic neurons	causes_apoptosis_of	cell_type	0.80
motor neurons	causes_degeneration_of	cell_type	0.80
demyelination	contributes_to	biological_process	0.80
Alzheimer's disease	implicated_in	disease	0.80
Parkinson's disease	implicated_in	disease	0.80
Huntington's disease	implicated_in	disease	0.80
amyotrophic lateral sclerosis	implicated_in	disease	0.80
amyloid-beta	contributes_to	compound	0.80
tau	contributes_to	protein	0.80
MKK7	activates	gene	0.80
neurodegeneration	associated_with	disease	0.80
Demyelination	involved_in	process	0.80
Tau Hyperphosphorylation	contributes_to	phenotype	0.80
MKK6	activates	protein	0.75
oxidative stress response	participates_in	pathway	0.70
apoptosis pathway	participates_in	pathway	0.70
motor_neurons	causes	cell_type	0.64
traumatic brain injury	protects_against	disease	0.60
RNA	regulates	gene	0.60
JNK	inhibits	gene	0.60

Incoming (16)

Source	Relation	Type	Str
OXIDATIVE_STRESS	activates	process	0.90
Endoplasmic_Reticulum_Stress	activates	process	0.90
Ginsenoside Compound K	targets	compound	0.90
Endoplasmic Reticulum Stress	activates	process	0.90
Oxidative Stress	activates	process	0.90
HTT	activates	gene	0.85
SOD1	activates	gene	0.85
APP	interacts_with	protein	0.85
SNCA	activates	gene	0.80
APP	mediates	protein	0.75
ER_stress	activates	phenotype	0.64
oxidative_stress	activates	phenotype	0.64
AKT	activates	gene	0.60
ASC	activates	gene	0.60
ALS	causes	gene	0.60
ALS	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity