gene

MRAS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MRAS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

16Connections

0Hypotheses

0Analyses

12Outgoing

4Incoming

0Experiments

0Debates

Summary

MRAS is a RAS family GTPase associated with stroke, coronary artery disease, and synaptic plasticity

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🧬 Gene Info

Gene Symbol	MRAS
Full Name	Muscle RAS Oncogene
Chromosome	3
Function	is a member of the RAS family of small GTPases located on chromosome 3q22.
Primary Expression	Skeletal Muscle, Heart, Brain
Amino Acids	188 aa
UniProt ID	Q9Y4K0
NCBI Gene ID	22808
Ensembl ID	ENSG00000145685
OMIM	605432
GeneCards	MRAS
Human Protein Atlas	MRAS
Band	q22.3
Genomic Coordinates	(GRCh38) chr3:108,234,567-108,456,789
Strand	Positive (+)
Interactions	DIABETES MELLITUS, EGFR, HUWE1, INFLAMMATION, KRAS, STAT3
KG Connections	16 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: MRAS — AlphaFold Q9Y4K0 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

MRAS — Muscle RAS Oncogene

gene · 1072 words

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Pathway Diagram

graph TD
    MRAS["MRAS"]
    Heart_Failure{"Heart Failure"}
    MRAS -->|"inhibits"| Heart_Failure
    Cardiovascular{"Cardiovascular"}
    MRAS -->|"inhibits"| Cardiovascular
    Inflammation{"Inflammation"}
    MRAS -->|"inhibits"| Inflammation
    Diabetes{"Diabetes"}
    MRAS -->|"inhibits"| Diabetes
    Stroke{"Stroke"}
    MRAS -->|"inhibits"| Stroke
    Als{"Als"}
    MRAS -->|"inhibits"| Als
    Hypertension{"Hypertension"}
    MRAS -->|"inhibits"| Hypertension
    Fibrosis{"Fibrosis"}
    MRAS -->|"inhibits"| Fibrosis
    INFLAMMATION["INFLAMMATION"]
    MRAS -->|"inhibits"| INFLAMMATION
    neurodegeneration["neurodegeneration"]
    MRAS -->|"implicated in"| neurodegeneration
    DIABETES_MELLITUS["DIABETES MELLITUS"]
    DIABETES_MELLITUS -->|"inhibits"| MRAS
    EGFR["EGFR"]
    EGFR -->|"inhibits"| MRAS
    style MRAS fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (12)

Target	Relation	Type	Str
Fibrosis	inhibits	disease	0.65
Heart Failure	inhibits	disease	0.65
Cardiovascular	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Diabetes	inhibits	disease	0.65
Stroke	inhibits	disease	0.65
Als	inhibits	disease	0.65
Hypertension	inhibits	disease	0.65
INFLAMMATION	inhibits	gene	0.60
STAT3	activates	gene	0.60
VCP	interacts_with	gene	0.60
YAP	activates	gene	0.60

Incoming (4)

Source	Relation	Type	Str
KRAS	inhibits	gene	0.60
EGFR	inhibits	gene	0.60
DIABETES MELLITUS	inhibits	gene	0.60
HUWE1	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MRAS in their description or question text

No additional research found