gene

NEK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NEK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

101Connections

0Hypotheses

1Analyses

50Outgoing

44Incoming

0Experiments

1Debates

Summary

NEK1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, implicated in. Associated with Als, Amyotrophic Lateral Sclerosis, Ms. Connected to 28 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NEK1
Full Name	NIMA Related Kinase 1
Chromosome	4q33
Protein Type	Serine/Threonine Kinase
Function	NEK1 is a multifunctional kinase with roles spanning several critical cellular processes.
Primary Expression	Motor cortex, Spinal cord, Widespread
Molecular Weight	145 kDa
UniProt ID	Q96PY6
NCBI Gene ID	4750
Ensembl ID	ENSG00000137601
OMIM	604588
GeneCards	NEK1
Human Protein Atlas	NEK1
Associated Diseases	Als, Amyotrophic Lateral Sclerosis, APOPTOSIS, Ms
Interactions	ALS, ANGPTL4, App, C21ORF2, CCNF, CHCHD10
KG Connections	101 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NEK1 — AlphaFold Q96PY6 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

NEK1 — NIMA Related Kinase 1

gene · 976 words

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NEK1 Protein

protein · 617 words

→

Pathway Diagram

graph TD
    NEK1["NEK1"]
    Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
    NEK1 -->|"therapeutic target"| Amyotrophic_Lateral_Sclerosis
    Ms{"Ms"}
    NEK1 -->|"therapeutic target"| Ms
    Als{"Als"}
    NEK1 -->|"associated with"| Als
    SOD1["SOD1"]
    NEK1 -->|"therapeutic target"| SOD1
    TBK1["TBK1"]
    NEK1 -->|"associated with"| TBK1
    neurodegeneration["neurodegeneration"]
    NEK1 -->|"implicated in"| neurodegeneration
    CHCHD10["CHCHD10"]
    CHCHD10 -->|"associated with"| NEK1
    C21ORF2["C21ORF2"]
    C21ORF2 -->|"associated with"| NEK1
    GENES["GENES"]
    GENES -->|"associated with"| NEK1
    DNA["DNA"]
    DNA -->|"therapeutic target"| NEK1
    SOD1 -->|"therapeutic target"| NEK1
    style NEK1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (57)

Target	Relation	Type	Str
Amyotrophic Lateral Sclerosis	causes	disease	0.85
oxidative stress response	participates_in	pathway	0.80
ALS	causes	disease	0.70
Amyotrophic Lateral Sclerosis	implicated_in	disease	0.65
Als	associated_with	disease	0.65
AMYOTROPHIC LATERAL SCLEROSIS	interacts_with	disease	0.65
HDAC6	causes	gene	0.65
C9orf72	exacerbates	gene	0.65
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Ms	associated_with	disease	0.65
Als	inhibits	disease	0.65
Amyotrophic Lateral Sclerosis	regulates	disease	0.65
NEURONS	activates	cell_type	0.65
App	inhibits	protein	0.60
SOD1	causes	gene	0.60
HEDGEHOG	associated_with	gene	0.60
HDAC	therapeutic_target	gene	0.60
Hedgehog	associated_with	pathway	0.60
SETX	causes	gene	0.60
NEURODEGENERATIVE DISEASES	associated_with	gene	0.60
SOD1	therapeutic_target	gene	0.60
C21ORF2	associated_with	gene	0.60
CHCHD10	associated_with	gene	0.60
Stat3	inhibits	protein	0.60
ALS	regulates	disease	0.60
TBP	implicated_in	gene	0.60
VCP	associated_with	gene	0.60
GENES	associated_with	gene	0.60
DNA	therapeutic_target	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	therapeutic_target	gene	0.60
Dna Repair	therapeutic_target	pathway	0.60
blood-brain barrier	participates_in	pathway	0.60
apoptosis pathway	participates_in	pathway	0.60
necroptosis	participates_in	pathway	0.60
endothelial cells	expressed_in	cell_type	0.60
TBK1	associated_with	gene	0.60
TBK1	causes	gene	0.60
VCP	causes	gene	0.60
OPTN	associated_with	gene	0.60
SOD1	associated_with	gene	0.60
MOTOR NEURONS	implicated_in	gene	0.60
TARDBP	associated_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	implicated_in	gene	0.60
MITOCHONDRIAL DYSFUNCTION	therapeutic_target	gene	0.60
TARDBP	causes	gene	0.60
NEK7	associated_with	gene	0.60
RIPK1	activates	gene	0.60
RIPK1	protects_against	gene	0.60
RIPK1	inhibits	gene	0.60

Incoming (44)

Source	Relation	Type	Str
ALS	associated_with	gene	0.70
GENES	associated_with	gene	0.60
DNA	therapeutic_target	gene	0.60
MATR3	associated_with	gene	0.60
FUS	associated_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	regulates	gene	0.60
MOTOR NEURONS	associated_with	gene	0.60
AND	therapeutic_target	gene	0.60
ALS	regulates	gene	0.60
DNA	causes	gene	0.60
ALS	inhibits	gene	0.60
CHCHD10	associated_with	gene	0.60
C21ORF2	associated_with	gene	0.60
SOD1	therapeutic_target	gene	0.60
FIG4	causes	gene	0.60
AND	associated_with	gene	0.60
MITOCHONDRIAL DYSFUNCTION	therapeutic_target	gene	0.60
HIF	activates	gene	0.60
ALS	causes	gene	0.60
ALS	activates	gene	0.60
HDAC6	therapeutic_target	gene	0.60
TUBULIN	causes	gene	0.60
STAT3	inhibits	gene	0.60
HDAC8	activates	gene	0.60
CCNF	interacts_with	gene	0.60
CHCHD10	interacts_with	gene	0.60
DCBLD1	interacts_with	gene	0.60
C21ORF2	interacts_with	gene	0.60
KIF5A	interacts_with	gene	0.60
C21ORF2	activates	gene	0.60
C21ORF2	regulates	gene	0.60
ALS	interacts_with	gene	0.60
MATR3	interacts_with	gene	0.60
ANGPTL4	interacts_with	gene	0.60
TBK1	associated_with	gene	0.60
FUS	causes	gene	0.60
CCNF	implicated_in	gene	0.60
CTSF	implicated_in	gene	0.60
DNAJC7	implicated_in	gene	0.60
GLT8D1	implicated_in	gene	0.60
KIF5A	implicated_in	gene	0.60
MFSD8	implicated_in	gene	0.60
HDAC6	inhibits	gene	0.60
DNA	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How do the seven novel ALS genes function in animal models to cause neurodegener

neurodegeneration | 2026-04-13 | 1 hypotheses Top: 0.724

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The authors explicitly state that the effects of these novel genes (MATR3, CHCHD

closed · Rounds: 4 · Score: 0.71 · 2026-04-14

Related Research

Hypotheses and analyses mentioning NEK1 in their description or question text

No additional research found