protein 1,674 words KG: HDAC4PROTEIN
Contents

HDAC4 Protein

🔬 Protein Info
Gene SymbolHDAC4
Full NameHistone Deacetylase 4
AliasesHDAC4PROTEIN
Chromosome2q37.3
Protein FamilyHistone deacetylase, Class IIa
FunctionHistone Modification: Removes acetyl groups from lysine tails of histones H3 and H4
Subcellular Localization</strong></td><td>Nucleus/Cytoplasm (signal-dependent)</td></tr>
Molecular Weight119 kDa
Amino Acids1088 aa
PathwaysNF-κB, AMPK
UniProt ID[P56524](https://www.uniprot.org/uniprot/P56524)
Ensembl IDENSG00000113048
OMIM605314
GeneCardsHDAC4
Human Protein AtlasHDAC4
Associated DiseasesAging, ALS, Alzheimer, dementia, Soft Tissue Sarcoma, Tumor
InteractionsAGING, AMPK, AND, App, AQP1, CAMKII
KG Connections181 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Related Hypotheses (7)

Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
HDAC3-Selective Inhibition for Clock Reset
Score: 0.71
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.67

Related Analyses (7)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (6)

SAHA@LIPO-ANG2 therapeutic efficacy in 5xFAD mice
validation · proposed · Score: 0.90
HDAC4 inhibition and NHE6 expression mechanism study
exploratory · proposed · Score: 0.85
Neuroimmune modulation and Aβ clearance mechanisms
exploratory · proposed · Score: 0.82
Epigenetic Dysregulation in Huntington's Disease — Therapeut
validation · proposed · Score: 0.40
Epigenetic Regulation Dysfunction in Alzheimer's and Parkins
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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