gene 638 words KG: HDAC4
Contents

HDAC4 Gene

🧬 Gene Info
Gene SymbolHDAC4
Full NameHistone Deacetylase 4
Chromosome2q37.3
Protein FamilyHistone deacetylase, Class IIa
FunctionHistone Modification: Removes acetyl groups from lysine tails of histones H3 and H4
Molecular Weight119 kDa
Amino Acids1088 aa
PathwaysNF-κB, AMPK
UniProt ID[P56524](https://www.uniprot.org/uniprot/P56524)
Ensembl IDENSG00000113048
OMIM605314
GeneCardsHDAC4
Human Protein AtlasHDAC4
Chromosomal location2q37.3
Gene familyHistone deacetylase, Class IIa
Associated DiseasesAging, ALS, Alzheimer, dementia, Soft Tissue Sarcoma, Tumor
InteractionsAGING, AMPK, AND, App, AQP1, CAMKII
KG Connections177 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (16)

Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77
Epigenetic Memory Erasure via TET2 Activation
Score: 0.74
CYP46A1 Overexpression Gene Therapy
Score: 0.73
HDAC3-Selective Inhibition for Clock Reset
Score: 0.71
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.71
Targeted Butyrate Supplementation for Microglial Phenotype M
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Osmotic Gradient Restoration via Selective AQP1 Enhancement
Score: 0.68
Partial Neuronal Reprogramming via Modified Yamanaka Cocktai
Score: 0.67
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Temporal TET2-Mediated Hydroxymethylation Cycling
Score: 0.66
Arginine Methylation Enhancement Therapy
Score: 0.65
KDM6A-Mediated H3K27me3 Rejuvenation
Score: 0.65
DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.65

Related Analyses (6)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (6)

SAHA@LIPO-ANG2 therapeutic efficacy in 5xFAD mice
validation · proposed · Score: 0.90
HDAC4 inhibition and NHE6 expression mechanism study
exploratory · proposed · Score: 0.85
Neuroimmune modulation and Aβ clearance mechanisms
exploratory · proposed · Score: 0.82
Epigenetic Dysregulation in Huntington's Disease — Therapeut
validation · completed · Score: 0.40
Epigenetic Regulation Dysfunction in Alzheimer's and Parkins
clinical · proposed · Score: 0.40

See Also (10)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: inhibits
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: inhibits
AQP1 Gene
gene · KG edge: co_mentioned
CD4 Gene
gene · KG edge: activates
CDK2 Gene
gene · KG edge: inhibits

Knowledge Graph (12 edges)

HDAC4 inhibits MEF2A
HDAC4 inhibits AQP1
HDAC7 associated_with HDAC4
PTEN associated_with HDAC4
MEF2A inhibits HDAC4
PI3K therapeutic_target HDAC4
HDAC4 therapeutic_target AKT
HDAC4 associated_with HDAC7
AQP1 inhibits HDAC4
AKT therapeutic_target HDAC4

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