Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GLP-1 Receptor: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
The glucagon-like peptide-1 receptor (GLP1R) is a class B G protein-coupled receptor activated by GLP-1 and GIP incretin hormones. In the brain, GLP1R activation promotes neuroprotection, reduces neuroinflammation, enhances synaptic plasticity, and improves mitochondrial function. GLP-1 receptor agonists (semaglutide, liraglutide, tirzepatide) are being investigated as disease-modifying therapies for Alzheimer's and Parkinson's disease.
Ontology: MESH:D000068878
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| Gene Symbol | GLP |
| Function | Glp 1 Receptor (Glucagon Like Peptide 1 Receptor) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function,... |
| GeneCards | GLP |
| Human Protein Atlas | GLP |
| Interactions | ERK, GSK-3β, PI3K |
| KG Connections | 12 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
| Target | Relation | Type | Str |
|---|---|---|---|
| Blood Sugar Levels | regulates | phenotype | 0.95 |
| Neuroinflammation | inhibits | process | 0.90 |
| Alzheimer's disease | therapeutic_target | disease | 0.90 |
| Insulin Signaling | activates | pathway | 0.90 |
| Blood Sugar Regulation | regulates | process | 0.90 |
| GSK-3β | inhibits | protein | 0.88 |
| PI3K | activates | protein | 0.87 |
| amyloid-β | prevents | protein | 0.85 |
| ERK | activates | protein | 0.85 |
| NEUROTROPHIC FACTORS | upregulates | protein | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-14 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning GLP-1 Receptor in their description or question text
No additional research found