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entity 994 words KG: GSK-3β
Contents

GSK-3β

🔬 Protein Info
Gene SymbolGSK
Full Name3β: Comprehensive Scientific Overview
FunctionGlycogen synthase kinase-3 beta (GSK-3β) is a serine/threonine kinase originally identified for its role in glycogen metabolism.
GeneCardsGSK
Human Protein AtlasGSK
Interactions14-3-3ζ, AKT, GLP-1R, Lithium, Pro-apoptotic Factors, tau
KG Connections16 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (15)

Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.87Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82Prefrontal sensory gating circuit restoration via PV interne
Score: 0.78Purinergic Signaling Polarization Control
Score: 0.71Noradrenergic-Tau Propagation Blockade
Score: 0.71Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.69Cross-Seeding Prevention Strategy
Score: 0.69Hypocretin-Neurogenesis Coupling Therapy
Score: 0.69Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.68Mitochondrial RNA Granule Rescue Pathway
Score: 0.66VCP-Mediated Autophagy Enhancement
Score: 0.59Temporal Decoupling via Circadian Clock Reset
Score: 0.54APOE-Dependent Autophagy Restoration
Score: 0.86Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73Brain Insulin Resistance with Glucose Transporter Dysfunctio
Score: 0.60

Related Analyses (10)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archivedAstrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archivedMicroglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archivedAPOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archivedSleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived

Related Experiments (3)

Tau depletion effects on neuronal development in primary cul
exploratory · proposed · Score: 0.90Microtubule domain analysis in adult axons
exploratory · proposed · Score: 0.80Pre-Symptomatic Tau Detection in MAPT Mutation Carriers
clinical · proposed · Score: 0.40

See Also (11)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activatesApoptosis in Neurodegeneration
entity · KG edge: activatesAmyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: causesBACE1 (Redirect)
redirect · KG edge: activatesAutophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: causes

Knowledge Graph (12 edges)

GSK-3β regulates MAPT
TAU associated_with GSK-3β
14-3-3ζ interacts_with GSK-3β
GLP-1R inhibits GSK-3β
GSK-3β promotes neurofibrillary tangle
GSK-3β activates Pro-apoptotic Factors
GSK-3β phosphorylates tau
AKT inhibits GSK-3β
AKT interacts_with GSK-3β
GSK-3β activates apoptosis

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