gene 867 words KG: GRM3
Contents

GRM3 — Glutamate Metabotropic Receptor 3

🧬 Gene Info
Gene SymbolGRM3
Full NameGlutamate Metabotropic Receptor 3
Chromosome7q21.12
Protein FamilyClass C GPCR, mGluR family
Protein TypeReceptor
FunctionmGluR3 is a presynaptic autoreceptor and postsynaptic receptor that
Subcellular Localization**: Presynaptic and postsynaptic membranes
Molecular Weight98 kDa
Amino Acids879 aa
PathwaysMAPK, PI3K, NF-κB
UniProt IDQ14832
NCBI Gene ID2915
Ensembl IDENSG00000138821
OMIM604099
GeneCardsGRM3
Human Protein AtlasGRM3
Associated Diseasesaging, Als, Alzheimer, Bipolar
InteractionsDAO, DISC1, G72, GRIN2B, GRM4, NCAM1
KG Connections124 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (6)

Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.84
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
Excitatory Neuron Vulnerability via SLC17A7 Downregulation
Score: 0.67

Related Analyses (5)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (15)

Bipolar Cells in Visual Processing
cell · KG edge: associated_with
BACE1 (Redirect)
redirect · KG edge: expressed_in
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: associated_with
Genes
index · KG edge: associated_with
BDNF Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

HTR2A associated_with GRM3
DISC1 associated_with GRM3
FKBP5 associated_with GRM3
NRG1 associated_with GRM3
DAO associated_with GRM3
BMAL1 associated_with GRM3
GRM4 associated_with GRM3
SYNGR1 associated_with GRM3
BDNF associated_with GRM3
NCAM1 associated_with GRM3

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