gene 1,090 words KG: GATA2
Contents

GATA2 - GATA Binding Protein 2

🧬 Gene Info
Gene SymbolGATA2
Full NameGATA Binding Protein 2
AliasesPage for GATA2
Protein TypeTranscription Factor
FunctionGATA2 functions as a dual-function transcription factor with roles in development and adult tissue homeostasis:
Primary Expressionpremigratory and migrating neural crest cells, where it regulates genes involved in melanocyte, Schwann cell, and peripheral neuron development
PathwaysApoptosis, Cholesterol
Ensembl IDENSG00000179348
GeneCardsGATA2
Human Protein AtlasGATA2
Associated DiseasesAls, Alzheimer, Infection, Inflammation, Lymphoma
InteractionsAKT, AND, ANG, AQP3, AQP4, CANCER
KG Connections162 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (7)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.78
Aquaporin-4 Polarization Rescue
Score: 0.73
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.68
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.67

Related Analyses (6)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · completed
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (12)

Apoptosis in Neurodegeneration
entity · KG edge: regulates
ANG — Angiogenin
gene · KG edge: activates
AQP4 (Aquaporin-4 Gene)
gene · KG edge: activates
ATF3 Gene
gene · KG edge: protects_against
ATM Gene
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

AQP4 activates GATA2
GATA3 activates GATA2
GATA2 regulates NFATC1
GATA2 activates MST1
TIMP1 therapeutic_target GATA2
GATA2 therapeutic_target PDGFRB
GATA2 therapeutic_target CHL1
PIK3CA therapeutic_target GATA2
PTK2B therapeutic_target GATA2
GATA2 therapeutic_target EGF

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