gene

FGF7

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FGF7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

48Connections

0Hypotheses

0Analyses

37Outgoing

11Incoming

0Experiments

0Debates

Summary

FGF7 (Fibroblast Growth Factor 7), also known as keratinocyte growth factor (KGF), is a paracrine growth factor that promotes epithelial cell proliferation, tissue repair, and has neuroprotective effects in the nervous system. Implicated in Alzheimer's disease, Parkinson's disease, and neural development.

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🧬 Gene Info

Gene Symbol	FGF7
Full Name	Fibroblast Growth Factor 7
Chromosome	19p13.3
Protein Type	Secreted growth factor
Function	is a member of the fibroblast growth factor family that functions primarily as a paracrine growth factor[@finch1998].
Primary Expression	various tissues including skin, lung, gastrointestinal tract, and brain, where it plays critical roles in tissue repair, morphogenesis, and cellular s
Molecular Weight	26 kDa
Amino Acids	194 aa
Pathways	MAPK pathway, PI3K
UniProt ID	P21781
NCBI Gene ID	2254
Ensembl ID	ENSG00000145681
OMIM	148180
GeneCards	FGF7
Human Protein Atlas	FGF7
Associated Diseases	Als
Interactions	Actin, Akt, AND, ASTROCYTE, ASTROCYTES, Fgf
KG Connections	48 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: FGF7 — AlphaFold P21781 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

FGF7 — Fibroblast Growth Factor 7

gene · 2584 words

→

FGF7 Protein

protein · 619 words

→

Pathway Diagram

graph TD
    FGF7["FGF7"]
    TRKB["TRKB"]
    TRKB -->|"regulates"| FGF7
    NTRK2["NTRK2"]
    NTRK2 -->|"regulates"| FGF7
    Parkinson["Parkinson"]
    FGF7 -->|"activates"| Parkinson
    Neuroinflammation["Neuroinflammation"]
    FGF7 -->|"activates"| Neuroinflammation
    Inflammation["Inflammation"]
    FGF7 -->|"activates"| Inflammation
    ASTROCYTES["ASTROCYTES"]
    FGF7 -->|"activates"| ASTROCYTES
    Dopaminergic["Dopaminergic"]
    FGF7 -->|"activates"| Dopaminergic
    Fibroblast["Fibroblast"]
    FGF7 -->|"associated with"| Fibroblast
    Neuron["Neuron"]
    FGF7 -->|"activates"| Neuron
    Astrocyte["Astrocyte"]
    FGF7 -->|"activates"| Astrocyte
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    FGF7 -->|"activates"| PARKINSON_S_DISEASE
    Astrocyte_Reactivity["Astrocyte Reactivity"]
    FGF7 -->|"associated with"| Astrocyte_Reactivity
    ASTROCYTE["ASTROCYTE"]
    ASTROCYTE -->|"activates"| FGF7
    FGFR2["FGFR2"]
    FGFR2 -->|"activates"| FGF7
    NEUROINFLAMMATION["NEUROINFLAMMATION"]
    NEUROINFLAMMATION -->|"activates"| FGF7
    INFLAMMATION["INFLAMMATION"]
    INFLAMMATION -->|"activates"| FGF7
    PARKINSON["PARKINSON"]
    PARKINSON -->|"activates"| FGF7
    FGF["FGF"]
    FGF -->|"activates"| FGF7
    AND["AND"]
    AND -->|"activates"| FGF7
    Fibroblast["Fibroblast"]
    FGF7 -->|"expressed in"| Fibroblast
    Astrocyte["Astrocyte"]
    FGF7 -->|"expressed in"| Astrocyte
    Neuron["Neuron"]
    FGF7 -->|"expressed in"| Neuron
    FGFR2["FGFR2"]
    FGF7 -->|"activates"| FGFR2
    NEURON["NEURON"]
    FGF7 -->|"co discussed"| NEURON
    PARKIN["PARKIN"]
    FGF7 -->|"co discussed"| PARKIN
    PARKINSON["PARKINSON"]
    FGF7 -->|"activates"| PARKINSON
    neurodegeneration["neurodegeneration"]
    FGF7 -->|"implicated in"| neurodegeneration

Outgoing (37)

Target	Relation	Type	Str
Cancer	activates	disease	0.65
Inflammation	activates	disease	0.65
Parkinson	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Als	associated_with	disease	0.65
Aging	therapeutic_target	disease	0.65
Fibrosis	activates	disease	0.65
astrocytes	expressed_in	cell_type	0.60
PARKINSON'S DISEASE	activates	gene	0.60
Astrocyte Reactivity	associated_with	pathway	0.60
ASTROCYTE	activates	gene	0.60
Akt	activates	protein	0.60
App	therapeutic_target	protein	0.60
Astrocyte	activates	cell_type	0.60
ASTROCYTES	activates	gene	0.60
Fgf	activates	protein	0.60
RAS	activates	gene	0.60
Dopaminergic	activates	cell_type	0.60
Fibroblast	associated_with	cell_type	0.60
Neuron	activates	cell_type	0.60
Epithelial	expressed_in	cell_type	0.60
Pi3K	activates	protein	0.60
Actin	activates	protein	0.60
Fibroblast	expressed_in	cell_type	0.55
Astrocyte	expressed_in	cell_type	0.55
Neuron	expressed_in	cell_type	0.55
FGFR2	associated_with	gene	0.50
PARKINSON	activates	gene	0.50
inflammation	activates	pathway	0.50
NEURONS	activates	concept	0.50
DOPAMINERGIC	activates	concept	0.50
DOPAMINERGIC NEURONS	activates	concept	0.50
inflammation	associated_with	pathway	0.50
Astrocyte	associated_with	cell_type	0.50
FGFR2	activates	gene	0.50
PARKIN	co_discussed	gene	0.50
NEURON	co_discussed	gene	0.50

Incoming (11)

Source	Relation	Type	Str
TRKB	regulates	protein	0.70
NTRK2	regulates	protein	0.70
NEUROINFLAMMATION	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
PARKINSON	activates	gene	0.60
FGF	activates	gene	0.60
AND	activates	gene	0.60
FGF	associated_with	gene	0.60
FGFR2	activates	gene	0.60
ASTROCYTE	activates	gene	0.60
Neuroinflammation	activates	process	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FGF7 in their description or question text

No additional research found