gene

B3GALT6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about B3GALT6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

5Connections

0Hypotheses

0Analyses

4Outgoing

1Incoming

0Experiments

0Debates

Summary

The B3GALT6 gene encodes beta-1,3-galactosyltransferase 6, a glycosyltransferase involved in glycosaminoglycan biosynthesis. This page covers its role in proteoglycan synthesis, connective tissue disorders, and implications for neurodegeneration.

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🧬 Gene Info

Gene Symbol	B3GALT6
Full Name	Beta-1,3-Galactosyltransferase 6
Chromosome	2q32.2
Protein Type	Transferase
Function	encodes a type II membrane-bound glycosyltransferase with a short cytoplasmic N-terminus, a transmembrane domain, and a catalytic domain facing the Golgi lumen.
Primary Expression	connective tissues throughout the body:
Exons	9
UniProt ID	[Q96MC4](https://www.uniprot.org/uniprotkb/Q96MC4/entry)
Ensembl ID	ENSG00000110717
GeneCards	B3GALT6
Human Protein Atlas	B3GALT6
Substrate	UDP-galactose + acceptor (typically a GlcA-containing trisaccharide)
Product	Galactosylated tetrasaccharide linker
Location	Golgi apparatus
Cooperation	Works together with B4GALT7 (beta-1,4-galactosyltransferase 7) in the linker region synthesis
Associated Diseases	neurodegeneration
Interactions	App, FGF, FGFR2
KG Connections	5 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

B3GALT6 Gene

gene · 1151 words

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Pathway Diagram

flowchart TD
    B3GALT6(["B3GALT6"])
    Cancer["Cancer"]
    FGF(["FGF"])
    App(["App"])
    Ras(["Ras"])
    FGFR2(["FGFR2"])
    neurodegeneration["neurodegeneration"]

    B3GALT6 -->|"activates"| Cancer
    B3GALT6 -->|"activates"| FGF
    B3GALT6 -.->|"inhibits"| App
    B3GALT6 -->|"regulates"| Ras
    FGFR2 -->|"activates"| B3GALT6
    B3GALT6 -->|"implicated in"| neurodegeneration

    style B3GALT6 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (4)

Target	Relation	Type	Str
Cancer	activates	disease	0.65
FGF	activates	gene	0.60
App	inhibits	protein	0.60
Ras	regulates	protein	0.60

Incoming (1)

Source	Relation	Type	Str
FGFR2	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning B3GALT6 in their description or question text

No additional research found