concept

PBRM1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PBRM1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

52Connections

0Hypotheses

0Analyses

41Outgoing

11Incoming

0Experiments

0Debates

No summary available yet.

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💡 Concept Info

Name	PBRM1
Key Genes/Proteins	AND, CANCER, DNA, ESR1, Fgf, FGFR2
Related Diseases	Als, biomarker_for, cancer, Cancer, Carcinoma

Pathway Diagram

graph TD
    PBRM1["PBRM1"]
    PBRM1 -->|"inhibits"| Clear_Cell_Renal_Cell_Carcinom["Clear Cell Renal Cell Carcinoma"]
    PBRM1 -->|"component_of"| SWI_SNF_Complex["SWI/SNF Complex"]
    PBRM1 -->|"modulates"| VHL_Loss["VHL Loss"]
    PBRM1 -->|"involved_in"| Chromatin_Remodeling["Chromatin Remodeling"]
    PBRM1 -->|"involved_in"| Tumor_Suppression["Tumor Suppression"]
    PBRM1 -->|"causes"| Cardiovascular["Cardiovascular"]
    PBRM1 -->|"causes"| Cancer["Cancer"]
    PBRM1 -->|"causes"| Carcinoma["Carcinoma"]
    MTOR["MTOR"] -->|"activates"| PBRM1
    CANCER["CANCER"] -->|"causes"| PBRM1
    VHL["VHL"] -->|"causes"| PBRM1
    HIF1["HIF1"] -->|"activates"| PBRM1
    STAT3["STAT3"] -->|"activates"| PBRM1
    DNA["DNA"] -->|"target for"| PBRM1

Outgoing (41)

Target	Relation	Type	Str
SWI/SNF complex	involved_in	pathway	0.95
Clear Cell Renal Cell Carcinoma	inhibits	disease	0.95
SWI/SNF Complex	component_of	pathway	0.90
Swi/Snf Complex	interacts_with	protein	0.90
Clear Cell Renal Cell Carcinoma	risk_factor_for	disease	0.90
VHL-Loss-Driven phenotype	associated_with	phenotype	0.85
VHL Loss	modulates	process	0.85
kidney tumorigenesis	suppresses	process	0.85
Chromatin Remodeling	involved_in	process	0.85
Kidney Tumorigenesis	involved_in	process	0.85
Kidney Cancer	protects_against	disease	0.85
biomarker_for	associated_with	phenotype	0.80
Tumor Suppression	involved_in	process	0.80
VHL	interacts_with	protein	0.75
Carcinoma	causes	disease	0.65
Cardiovascular	causes	disease	0.65
Cancer	causes	disease	0.65
Tumor	associated_with	disease	0.65
Als	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
PIK3CA	therapeutic_target	gene	0.60
FGFR2	associated_with	gene	0.60
Rb	associated_with	protein	0.60
Fgf	associated_with	protein	0.60
SNF	causes	gene	0.60
SWI	causes	gene	0.60
cancer	causes	disease	0.60
RB1	associated_with	gene	0.60
cancer	associated_with	disease	0.60
PCDH15	associated_with	gene	0.60
CANCER	causes	gene	0.60
VHL	causes	gene	0.60
Mtor	activates	pathway	0.60
VHL	associated_with	gene	0.60
STAT3	associated_with	gene	0.60
VHL	activates	gene	0.60
AND	causes	gene	0.60
MTOR	activates	gene	0.60
HIF1	associated_with	gene	0.60
Rb	causes	protein	0.60
Ras	causes	protein	0.60

Incoming (11)

Source	Relation	Type	Str
VHL	associated_with	gene	0.85
MTOR	activates	gene	0.60
HIF1	associated_with	gene	0.60
CANCER	causes	gene	0.60
VHL	causes	gene	0.60
STAT3	associated_with	gene	0.60
HIF1	activates	gene	0.60
STAT3	activates	gene	0.60
TPR	associated_with	gene	0.60
DNA	therapeutic_target	gene	0.60
ESR1	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PBRM1 in their description or question text

No additional research found