gene

PCDH15

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PCDH15: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

11Connections

0Hypotheses

0Analyses

6Outgoing

5Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	PCDH15
Full Name	Protocadherin 15
Chromosome	10q21.1
Protein Type	Gene
Function	is a member of the cadherin superfamily of cell adhesion molecules that plays critical roles in the development and maintenance of the auditory and vestibular systems.
Primary Expression	the stereocilia (hair bundle) of inner and outer hair cells in the cochlea - Vestibular system: Present in hair cells of the utricle, saccule, and
Subcellular Localization	the tips of stereocilia where mechanotransduction occurs
Molecular Weight	250 kDa
Amino Acids	307 aa
Exons	35
NCBI Gene ID	65217
GeneCards	PCDH15
Human Protein Atlas	PCDH15
Signal peptide	N-terminal 25 amino acids for secretory pathway targeting
Protocadherin repeats	11 extracellular cadherin (EC) domains, each approximately 110 amino acids, containing conserved calcium-binding motifs (DXNDN, DRE, DXD) at inter-domain boundaries
Associated Diseases	neurodegeneration
KG Connections	11 knowledge graph edges
Databases	GeneCards UniProt HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PCDH15 — Protocadherin 15

gene · 2425 words

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Pathway Diagram

graph TD
    PCDH15["PCDH15"]
    Als{"Als"}
    PCDH15 -->|"therapeutic_target"| Als
    Cancer{"Cancer"}
    PCDH15 -->|"therapeutic_target"| Cancer
    PIK3CA["PIK3CA"]
    PCDH15 -->|"therapeutic_target"| PIK3CA
    FGFR2["FGFR2"]
    PCDH15 -->|"associated_with"| FGFR2
    Rb("Rb")
    PCDH15 -->|"associated_with"| Rb
    Fgf("Fgf")
    PCDH15 -->|"associated_with"| Fgf
    TPR["TPR"]
    TPR -->|"associated_with"| PCDH15
    DNA["DNA"]
    DNA -->|"therapeutic_target"| PCDH15
    ESR1["ESR1"]
    ESR1 -->|"associated_with"| PCDH15
    PBRM1["PBRM1"]
    PBRM1 -->|"associated_with"| PCDH15
    RB1["RB1"]
    RB1 -->|"associated_with"| PCDH15
    neurodegeneration["neurodegeneration"]
    PCDH15 -->|"implicated_in"| neurodegeneration

Outgoing (6)

Target	Relation	Type	Str
Als	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Fgf	associated_with	protein	0.60
PIK3CA	therapeutic_target	gene	0.60
FGFR2	associated_with	gene	0.60
Rb	associated_with	protein	0.60

Incoming (5)

Source	Relation	Type	Str
DNA	therapeutic_target	gene	0.60
PBRM1	associated_with	gene	0.60
TPR	associated_with	gene	0.60
ESR1	associated_with	gene	0.60
RB1	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PCDH15 in their description or question text

No additional research found