gene 540 words KG: FGFR2
Contents

FGFR2 — Fibroblast Growth Factor Receptor 2

🧬 Gene Info
Gene SymbolFGFR2
Full NameFibroblast Growth Factor Receptor 2
Chromosome10q26
FunctionFGFR2 encodes fibroblast growth factor receptor 2, a receptor tyrosine kinase that primarily binds FGF7 and FGF10 (ligands with high specificity for FGFR2IIIb isoform).
Primary Expressionneural progenitors, astrocytes, and some neurons
PathwaysApoptosis, Chemoresistance, Stem Cell
UniProt ID[P21802](https://www.uniprot.org/uniprot/P21802)
Ensembl IDENSG00000166468
OMIM176943
GeneCardsFGFR2
Human Protein AtlasFGFR2
Associated DiseasesCancer, Cardiac, Ischemia
InteractionsActin, AND, App, ASTROCYTE, ASTROCYTES, AUTOPHAGY
KG Connections147 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (3)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.84
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72

Related Analyses (5)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (14)

Astrocytes
cell · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: regulates
Astrocytes
entity · KG edge: activates
astrocyte-neuron-metabolic-coupling-parkinsons
general · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: inhibits

Knowledge Graph (12 edges)

TP53 regulates FGFR2
FGFR2 regulates GFRA1
IDH1 therapeutic_target FGFR2
BRAF therapeutic_target FGFR2
CD44 activates FGFR2
FGFR2 inhibits EGFR
BRAF biomarker_for FGFR2
NRG1 biomarker_for FGFR2
TP53 biomarker_for FGFR2
FGFR1 biomarker_for FGFR2

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