gene 1,145 words KG: FERMT2
Contents

FERMT2 Gene

🧬 Gene Info
Gene SymbolFERMT2
Full NameFermitin Family Member 2
Chromosome14q22.1
Protein TypeReceptor
Functionencodes a member of the fermitin family of proteins.
Subcellular LocalizationKindlin-2 is prima
Molecular Weight80 kDa
Amino Acids683 aa
PathwaysInvasion, Wnt, Wnt/β-catenin signaling pathway
UniProt IDQ9BUF5
NCBI Gene ID10979
Ensembl IDENSG00000173702
OMIM614365
GeneCardsFERMT2
Human Protein AtlasFERMT2
Associated DiseasesAls, Alzheimer, Alzheimer's disease, CARCINOMA, Ms
InteractionsABCA7, ALZHEIMER, ALZHEIMER'S DISEASE, APOE, App,
KG Connections117 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (6)

Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
Piezoelectric Nanochannel BBB Disruption
Score: 0.52

Related Analyses (4)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (11)

ABCA7 (Redirect)
redirect · KG edge: activates
ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: associated_with
ATXN2 Gene
gene · KG edge: associated_with
BIN1 — Bridging Integrator 1
gene · KG edge: activates
CACNA1A — Calcium Channel Alpha-1A Subunit
gene · KG edge: associated_with

Knowledge Graph (12 edges)

ATXN2 associated_with FERMT2
CACNA1A associated_with FERMT2
CHAT associated_with FERMT2
FERMT2 associated_with OPTN
FERMT2 associated_with ABCA1
FERMT2 associated_with DPM2
FERMT2 associated_with TBK1
ABCA1 associated_with FERMT2
TBK1 associated_with FERMT2
OPTN associated_with FERMT2

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