| Gene Symbol | FERMITIN2 |
| Aliases | FERMITIN2PROTEIN |
| Subcellular Localization | to the plasma membrane through phosphatidylinositol (PIP2) binding |
| GeneCards | FERMITIN2 |
| Human Protein Atlas | FERMITIN2 |
| Kindlin-1 (FERMT1) | Epithelial expression — mutations cause Kindler syndrome |
| Kindlin-3 (FERMT3) | Hematopoietic expression — essential for platelet and immune cell integrin activation |
| Inside-out signaling | In response to cellular cues, fermitin-2 is recruited to integrin cytoplasmic tails via its FERM domain |
| Integrin priming | Binding to the β cytoplasmic tail relieves the autoinhibited state of the integrin heterodimer |
| Talin cooperation | The talin-fermitin-2 partnership is the validated mechanism for converting inactive into active integrins |
| Ligand binding | Activated integrins bind to ECM proteins (fibronectin, collagen, laminin) with high affinity |
| Adhesome recruitment | Fermitin-2 recruits paxillin, vinculin, and other adhesion proteins to nascent focal adhesions |
| Actin linkage | Via its C-terminal region, fermitin-2 links activated integrins to the actin cytoskeleton |
| Focal adhesion maturation | Promotes growth and stabilization of focal adhesions through mechanosensing |
| Turnover regulation | Controls focal adhesion disassembly during cell migration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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