concept

DIO2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DIO2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

21Connections

0Hypotheses

0Analyses

16Outgoing

5Incoming

0Experiments

0Debates

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💡 Concept Info

Name	DIO2
Key Genes/Proteins	AND, APOPTOSIS, MCT8, MITOCHONDRIA
Related Diseases	Als, ALS, Fibrosis, Lung Fibrosis
Related Pathways	Apoptosis, Mitochondrial Function, oxidative stress response

Pathway Diagram

graph TD
    DIO2["DIO2"]
    DIO2 -->|"activates"| Thyroid_Hormone["Thyroid Hormone"]
    DIO2 -.biomarker for.-> Idiopathic_Pulmonary_Fibrosis["Idiopathic Pulmonary Fibrosis"]
    DIO2 -->|"correlates_with"| Lung_Fibrosis["Lung Fibrosis"]
    DIO2 -->|"activates"| ALS["ALS"]
    DIO2 -->|"activates"| Fibrosis["Fibrosis"]
    DIO2 -->|"activates"| Als["Als"]
    DIO2 -->|"expressed in"| AND["AND"]
    DIO2 -->|"activates"| APOPTOSIS["APOPTOSIS"]
    PPARGC1A["PPARGC1A"] -->|"activates"| DIO2
    PINK1["PINK1"] -->|"activates"| DIO2
    MITOCHONDRIA["MITOCHONDRIA"] -->|"activates"| DIO2
    APOPTOSIS -->|"activates"| DIO2

Outgoing (16)

Target	Relation	Type	Str
Lung Fibrosis	correlates_with	disease	0.80
Als	activates	disease	0.65
Fibrosis	activates	disease	0.65
ALS	activates	disease	0.65
Tgf-Β	activates	pathway	0.60
Apoptosis	activates	pathway	0.60
Mitochondrial Function	activates	pathway	0.60
AND	expressed_in	gene	0.60
APOPTOSIS	activates	gene	0.60
Epithelial	activates	cell_type	0.60
Stem Cell	associated_with	cell_type	0.60
Oligodendrocyte	associated_with	cell_type	0.60
Oligodendrocyte Precursor	associated_with	cell_type	0.60
TH	activates	gene	0.60
oxidative stress response	participates_in	pathway	0.60
Epithelial Cell	expressed_in	cell_type	0.55

Incoming (5)

Source	Relation	Type	Str
PPARGC1A	activates	gene	0.60
PINK1	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
MCT8	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DIO2 in their description or question text

No additional research found