protein

COFILIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about COFILIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

49Connections

0Hypotheses

0Analyses

36Outgoing

13Incoming

0Experiments

0Debates

Summary

COFILIN is a protein involved in neurodegeneration research. Key relationships include: inhibits, expressed in, implicated in. Associated with Alzheimer. Connected to 12 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	COFILIN
Aliases	Actin-Depolymerizing Factor
Function	Cofilin-1 is a key regulator of actin cytoskeleton dynamics
Molecular Weight	19 kDa
GeneCards	COFILIN
Human Protein Atlas	COFILIN
Actin-binding interface	Binds to both G-actin (globular) and F-actin (filamentous) forms
Phosphoinositide-binding site	Enables membrane localization and regulation by phosphoinositides
Nuclear localization signal (NLS)	Allows translocation to the nucleus
Phosphorylation site	Ser3 phosphorylation regulates activity
Associated Diseases	neurodegeneration
Interactions	ALZHEIMER, ALZHEIMER'S DISEASE, AND, APOPTOSIS, EFHD2, INFLAMMATION
KG Connections	44 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Cofilin-1 — Actin-Depolymerizing Factor

protein · 923 words

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Pathway Diagram

graph TD
    COFILIN["COFILIN"]
    Alzheimer{"Alzheimer"}
    COFILIN -->|"inhibits"| Alzheimer
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    COFILIN -->|"inhibits"| ALZHEIMER_S_DISEASE
    PUMA["PUMA"]
    COFILIN -->|"inhibits"| PUMA
    ALZHEIMER["ALZHEIMER"]
    COFILIN -->|"inhibits"| ALZHEIMER
    Neuron["Neuron"]
    COFILIN -->|"expressed in"| Neuron
    Fibroblast["Fibroblast"]
    COFILIN -->|"expressed in"| Fibroblast
    Stem_Cell["Stem Cell"]
    COFILIN -->|"expressed in"| Stem_Cell
    neurodegeneration["neurodegeneration"]
    COFILIN -->|"implicated in"| neurodegeneration
    LIMK1["LIMK1"]
    LIMK1 -->|"inhibits"| COFILIN
    ALZHEIMER_S_DISEASE -->|"inhibits"| COFILIN
    ALZHEIMER -->|"inhibits"| COFILIN
    AND["AND"]
    AND -->|"inhibits"| COFILIN
    PUMA -->|"inhibits"| COFILIN
    style COFILIN fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (36)

Target	Relation	Type	Str
Neuronal Functional Alterations	associated_with	phenotype	0.90
Mitophagy	activates	process	0.82
ALS	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Alzheimer	inhibits	disease	0.65
Als	inhibits	disease	0.65
ALZHEIMER'S DISEASE	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
TNFR1	inhibits	gene	0.60
TNF	inhibits	gene	0.60
Apoptosis	inhibits	pathway	0.60
Epithelial	inhibits	cell_type	0.60
INFLAMMATION	inhibits	gene	0.60
AND	inhibits	gene	0.60
PUMA	inhibits	gene	0.60
Actin	expressed_in	protein	0.60
APOPTOSIS	inhibits	gene	0.60
LIMK1	regulates	entity	0.60
LIMK1	inhibits	gene	0.60
Rb	inhibits	protein	0.60
Neuron	regulates	cell_type	0.60
EFHD2	inhibits	gene	0.60
Raf	inhibits	protein	0.60
Epithelial Cell	expressed_in	cell_type	0.55
Fibroblast	expressed_in	cell_type	0.55
Stem Cell	expressed_in	cell_type	0.55
Neuron	expressed_in	cell_type	0.55
inflammation	inhibits	pathway	0.50
apoptosis	inhibits	process	0.50
NEURONS	inhibits	concept	0.50
ALZHEIMER'S	inhibits	concept	0.50
Alzheimer'S Disease	inhibits	disease	0.50
NEURONS	expressed_in	concept	0.50
NEURONS	regulates	concept	0.50
disease	inhibits	disease	0.50

Incoming (13)

Source	Relation	Type	Str
LIMK1	interacts_with	gene	0.95
EFHD2	interacts_with	protein	0.90
LIMK1	regulates	protein	0.80
ALZHEIMER'S DISEASE	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
LIMK1	inhibits	gene	0.60
PUMA	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60
EFHD2	inhibits	gene	0.60
TNF	inhibits	gene	0.60
TNFR1	inhibits	gene	0.60
INFLAMMATION	inhibits	gene	0.60
AND	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning COFILIN in their description or question text

No additional research found