concept

QUERCETIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about QUERCETIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

376Connections

1Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

9Debates

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💡 Concept Info

Name	QUERCETIN
Key Genes/Proteins	ABCA1, ACHE, AKT, AKT1, AMPK, AMYLOID
Related Diseases	AGING, ALZHEIMER, Alzheimer Disease, Alzheimer'S Disease, ALZHEIMER'S DISEASE

Pathway Diagram

graph TD
    QUERCETIN["QUERCETIN"]
    QUERCETIN -.protects against.-> Diabetic_Nephropathy["Diabetic Nephropathy"]
    QUERCETIN -->|"inhibits"| Renal_Tubular_Epithelial_Cell_["Renal Tubular Epithelial Cell Apoptosis"]
    QUERCETIN -->|"inhibits"| Neuronal_Pyroptosis["Neuronal Pyroptosis"]
    QUERCETIN -->|"inhibits"| PI3K_AKT["PI3K/AKT"]
    QUERCETIN -->|"treats"| Cerebral_Ischemia_Reperfusion_["Cerebral Ischemia/Reperfusion Injury"]
    QUERCETIN -->|"regulates"| PI3K_Akt_NF__B_Signaling_Pathw["PI3K/Akt/NF-kappaB Signaling Pathway"]
    QUERCETIN -.protects against.-> HK_2_Cells["HK-2 Cells"]
    QUERCETIN -->|"modulates"| Microglial_M1_M2_Polarization["Microglial M1/M2 Polarization"]
    MICROGLIA["MICROGLIA"] -->|"inhibits"| QUERCETIN
    ENDOTHELIAL_CELLS["ENDOTHELIAL CELLS"] -->|"target for"| QUERCETIN
    DASATINIB["DASATINIB"] -->|"target for"| QUERCETIN
    CANCER["CANCER"] -->|"regulates"| QUERCETIN
    MACROPHAGES["MACROPHAGES"] -->|"activates"| QUERCETIN
    ISCHEMIA["ISCHEMIA"] -->|"activates"| QUERCETIN

Outgoing (236)

Target	Relation	Type	Str
Microglia/Macrophages M2 Polarization	associated_with	process	0.95
Microglia M1/M2 Polarization	modulates	process	0.95
Neuronal Pyroptosis	inhibits	process	0.95
Diabetic Nephropathy	protects_against	disease	0.95
Renal Tubular Epithelial Cell Apoptosis	inhibits	process	0.95
Cellular Senescence	inhibits	process	0.95
Senescent Human Endothelial Cells	treats	cell_type	0.95
ROS	modulates	process	0.95
TNF-α Induced Apoptosis	inhibits	process	0.95
Nrf2/Ho1 Pathway	activates	pathway	0.95
Inflammation	inhibits	process	0.95
PI3K/AKT	inhibits	pathway	0.93
NF-κB	downregulates	pathway	0.92
AP-1	downregulates	pathway	0.92
Cognitive Deficits	treats	phenotype	0.92
ALZHEIMER'S DISEASE	treats	disease	0.90
Cerebral Ischemia/Reperfusion Injury	treats	disease	0.90
ferroptosis	inhibits	process	0.90
PI3K/Akt/NF-κB Signaling Pathway	regulates	pathway	0.90
Neuroinflammation	inhibits	process	0.90
NFE2L2	activates	gene	0.90
NF-κB	inhibits	protein	0.90
ANTIOXIDANT DEFENSE	activates	mechanism	0.90
Microglial M1/M2 Polarization	modulates	process	0.90
HK-2 Cells	protects_against	cell_type	0.90
Alzheimer'S Disease	treats	disease	0.90
Senescent Cells	targets	cell_type	0.90
AMPK	activates	protein	0.85
Type 2 Diabetes Mellitus	contributes_to	disease	0.85
INFLAMMATION	inhibits	process	0.85
Neurological Deficits	associated_with	disease	0.85
iron homeostasis	regulates	process	0.85
Infarct Volume	associated_with	biomarker	0.85
DEMENTIA	treats	disease	0.85
Neurodegeneration	protects_against	process	0.85
Neuroinflammation	protects_against	process	0.85
Cancer Signaling Pathways	modulates	pathway	0.80
JNK	binds_to	protein	0.80
senescent cells	associated_with	cell_type	0.80
Senescent cell survival	suppresses	process	0.80
Antioxidant Activity	involved_in	mechanism	0.80
PI3K/Akt/NF-κB	inhibits	pathway	0.80
Anti-apoptotic Activity	involved_in	mechanism	0.80
Anti-inflammatory Activity	involved_in	mechanism	0.80
IL-6	inhibits	protein	0.78
Aging	protects_against	process	0.75
JNK	interacts_with	protein	0.75
senolytic_therapy	associated_with	drug	0.75
senescence	modulates	pathway	0.75
kidney disease	treats	disease	0.75

Incoming (140)

Source	Relation	Type	Str
37679434	was not detected	paper	0.90
32093448	decreases	paper	0.90
32093448	is	paper	0.90
APP	activates	gene	0.70
MACROPHAGE	protects_against	cell_type	0.65
MICROGLIA	protects_against	cell_type	0.65
DIABETES	causes	disease	0.65
NEURODEGENERATION	causes	disease	0.65
ALZHEIMER	treats	disease	0.65
ALZHEIMER'S DISEASE	treats	disease	0.65
DIABETES	treats	disease	0.65
MAPK	targets	gene	0.65
32093448	prevents	paper	0.60
32093448	may be beneficial in	paper	0.60
apoptosis	inhibits	process	0.50
ENDOTHELIAL CELLS	associated_with	cell_type	0.50
Nephropathy	inhibits	disease	0.50
PI3K/AKT PATHWAY	inhibits	concept	0.50
apoptosis	activates	process	0.50
DIABETES MELLITUS	activates	concept	0.50
Epithelial Cell	activates	cell_type	0.50
Type 2 Diabetes	activates	disease	0.50
apoptosis	protects_against	process	0.50
Epithelial Cell	protects_against	cell_type	0.50
ferroptosis	inhibits	phenotype	0.50
atherosclerosis	inhibits	disease	0.50
Pyroptosis	inhibits	pathway	0.50
Neuroinflammation	associated_with	process	0.50
Neurodegeneration	associated_with	disease	0.50
inflammation	associated_with	pathway	0.50
Neuroinflammation	inhibits	process	0.50
AMYLOID	inhibits	gene	0.50
MICROGLIAL ACTIVATION	associated_with	phenotype	0.50
COGNITIVE DECLINE	associated_with	phenotype	0.50
OXIDATIVE STRESS	associated_with	phenotype	0.50
SYNAPTIC LOSS	associated_with	phenotype	0.50
HIPPOCAMPUS	associated_with	brain_region	0.50
SENESCENCE	associated_with	phenotype	0.50
ASTROCYTES	associated_with	cell_type	0.50
PHAGOCYTOSIS	associated_with	phenotype	0.50
CGAS-STING PATHWAY	associated_with	pathway	0.50
STING PATHWAY	associated_with	pathway	0.50
Pi3K	inhibits	pathway	0.50
Epithelial Cell	inhibits	cell_type	0.50
Pi3K/Akt	inhibits	pathway	0.50
ALZHEIMER'S	regulates	concept	0.50
microglia	regulates	cell_type	0.50
ALZHEIMER	regulates	gene	0.50
Alzheimer'S Disease	regulates	disease	0.50
disease	regulates	disease	0.50