concept

CAMKII

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CAMKII: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

152Connections

1Hypotheses

4Analyses

50Outgoing

45Incoming

4Experiments

20Debates

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💡 Concept Info

Name	CAMKII
Key Genes/Proteins	Actin, Adiponectin, AEP, AGING, AKT, ALZHEIMER
Related Diseases	Addiction, Aging, Als, ALS, Alzheimer
Related Pathways	Angiogenesis

🧬 3D Structure: CAMKII — PDB 3SOA Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Pathway Diagram

graph TD
    CAMKII["CAMKII"]
    style CAMKII fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    CAMKII -->|"activates"| HEPATIC_MITOCHONDRIAL_OXIDATIO["HEPATIC MITOCHONDRIAL OXIDATION"]
    CAMKII -->|"expressed in"| Pyramidal_Neurons["/Pyramidal Neurons/"]
    CAMKII -->|"regulates"| Hepatic_Mitochondrial_Oxidatio["Hepatic Mitochondrial Oxidation"]
    CAMKII -->|"regulates"| Intrahepatic_Lipolysis["Intrahepatic Lipolysis"]
    CAMKII -->|"regulates"| Gluconeogenesis["Gluconeogenesis"]
    CAMKII -->|"activates"| INTRAHEPATIC_LIPOLYSIS["INTRAHEPATIC LIPOLYSIS"]
    CAMKII -->|"regulates"| GLUCONEOGENESIS["GLUCONEOGENESIS"]
    CAMKII -->|"phosphorylates"| SAP97([SAP97])
    CAMKII -->|"regulates"| mitochondrial_oxidation["mitochondrial oxidation"]
    Cytosolic_Calcium["Cytosolic Calcium"] -->|"activates"| CAMKII
    CYTOSOLIC_CALCIUM["CYTOSOLIC CALCIUM"] -->|"activates"| CAMKII
    GluN2B([GluN2B]) -->|"activates"| CAMKII
    DLAT([DLAT]) -->|"regulates"| CAMKII
    AMPK([AMPK]) -->|"activates"| CAMKII
    FOXO1([FOXO1]) -->|"activates"| CAMKII
    FOXO4([FOXO4]) -->|"activates"| CAMKII
    AXON([AXON]) -->|"regulates"| CAMKII
    NEURON([NEURON]) -.->|"inhibits"| CAMKII

Outgoing (107)

Target	Relation	Type	Str
Pyramidal Neurons	expressed_in	cell_type	0.95
HEPATIC MITOCHONDRIAL OXIDATION	activates	entity	0.95
Hepatic Mitochondrial Oxidation	regulates	process	0.90
Intrahepatic Lipolysis	regulates	process	0.90
Gluconeogenesis	regulates	process	0.90
INTRAHEPATIC LIPOLYSIS	activates	entity	0.90
Cardiovascular	associated_with	disease	0.90
GLUCONEOGENESIS	regulates	entity	0.85
gluconeogenesis	mediates	process	0.80
hepatic mitochondrial oxidation	mediates	process	0.80
intrahepatic lipolysis	mediates	process	0.80
SAP97	regulates	protein	0.80
SAP97	phosphorylates	protein	0.80
spine generation	causes (CaMKII-dependent process that promotes spine gener)	mechanism	0.75
dendrite ramification	causes (CaMKII enhancement promotes dendrite ramification )	mechanism	0.75
tau release	regulates	phenotype	0.70
ERK1/2	activates	protein	0.70
synapsin-1 phosphorylation	activates	mechanism	0.70
Als	regulates	disease	0.65
Alzheimer	activates	disease	0.65
Senescence	inhibits	disease	0.65
Als	activates	disease	0.65
ALS	activates	disease	0.65
Als	inhibits	disease	0.65
Aging	inhibits	disease	0.65
Cardiovascular	inhibits	disease	0.65
Addiction	regulates	disease	0.65
Ischemia	associated_with	disease	0.65
Aging	activates	disease	0.65
Stroke	activates	disease	0.65
Depression	activates	disease	0.65
Inflammation	expressed_in	disease	0.65
Heart Failure	expressed_in	disease	0.65
Oxidative Stress	expressed_in	pathway	0.60
AXON	regulates	gene	0.60
Calmodulin	regulates	protein	0.60
AUTOPHAGY	regulates	gene	0.60
LYSOSOME	regulates	gene	0.60
Autophagy	regulates	pathway	0.60
Neuron	associated_with	cell_type	0.60
AQP1	transports	gene	0.60
MEF2A	inhibits	gene	0.60
AGING	inhibits	gene	0.60
Epigenetic	inhibits	pathway	0.60
Angiogenesis	inhibits	pathway	0.60
AMPK	activates	gene	0.60
FOXO	activates	gene	0.60
FOXO1	activates	gene	0.60
FOXO4	activates	gene	0.60
Actin	activates	protein	0.60

Incoming (45)

Source	Relation	Type	Str
CYTOSOLIC CALCIUM	activates	entity	0.95
Cytosolic Calcium	activates	compound	0.95
38890273	showed increased association with	paper	0.90
38890273	has increased association with	paper	0.90
GluN2B	activates	protein	0.70
DLAT	regulates	gene	0.70
FOXO1	activates	gene	0.60
FOXO4	activates	gene	0.60
AMPK	regulates	gene	0.60
NEURON	inhibits	gene	0.60
EXERCISE	regulates	gene	0.60
DNA	inhibits	gene	0.60
AMPK	transports	gene	0.60
HDAC4	inhibits	gene	0.60
AMPK	activates	gene	0.60
DEPRESSION	activates	gene	0.60
MTOR	activates	gene	0.60
EEF2	activates	gene	0.60
TNF	inhibits	gene	0.60
IL3	inhibits	gene	0.60
IL1B	inhibits	gene	0.60
AXON	regulates	gene	0.60
ALZHEIMER	activates	gene	0.60
IL-1	activates	gene	0.60
AEP	inhibits	gene	0.60
ERK	associated_with	gene	0.60
HDAC	activates	gene	0.60
CREB	associated_with	gene	0.60
HDAC2	activates	gene	0.60
OXIDATIVE STRESS	expressed_in	gene	0.60
INFLAMMATION	expressed_in	gene	0.60
MCU	activates	gene	0.60
CHR2	activates	gene	0.60
JUN	activates	gene	0.60
NEURON	activates	gene	0.60
STROKE	activates	gene	0.60
BDNF	activates	gene	0.60
PINK1	associated_with	gene	0.60
ERK1	associated_with	gene	0.60
PARK2	associated_with	gene	0.60
ERK1/2	associated_with	gene	0.60
AKT	activates	gene	0.60
MAP2	activates	gene	0.60
AKT	associated_with	gene	0.60
FOXO	activates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
CaMKII-Dependent Synaptic Circuit Amplification	0.611	neuroscience	Circuit-level neural dynamics in neurode

Mentioning Analyses (4)

Scientific analyses that reference this entity

What evidence supports Cdk5 activation as THE primary cause of AD versus other e

neurodegeneration | 2026-04-10 | 0 hypotheses

Which tau propagation mechanism predominates in different brain regions and dise

neurodegeneration | 2026-04-07 | 6 hypotheses Top: 0.740

Quantitative proteomics of the aging synapse in early Alzheimer disease

neurodegeneration | 2026-04-04 | 3 hypotheses Top: 0.455

Circuit-level neural dynamics in neurodegeneration

neuroscience | 2026-04-03 | 73 hypotheses Top: 0.968

Experiments (4)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Model	Status	Est. Cost
Sex differences in CB1R-mediated cannabinoid analgesia in neuropathic	validation	neuropathic pain	0.900	C57BL/6J mice (8-12 weeks old)	proposed	N/A
Conditional CB1R knockout in mPFC CaMKIIα neurons	validation	neuropathic pain	0.900	CB1R-floxed mice with conditio	proposed	N/A
Electrophysiological analysis of mPFC-vlPAG synaptic transmission	exploratory	neuropathic pain	0.850	Mouse brain slices from C57BL/	proposed	N/A
CB1R expression mapping in mPFC-vlPAG circuit	exploratory	neuropathic pain	0.850	GAD2-Cre-tdTomato mice, CB1R-i	proposed	N/A

Related Papers (5)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Chaperone-mediated autophagy as a sex-specific modulator of synaptic proteostasi [PMID:41358563]	Luo R	Autophagy	2026
The mPFC molecular clock mediates the effects of sleep deprivation on depression [PMID:41023421]	Gardner W, Sarrazin DH, Balzinger M, Mar	Mol Psychiatry	2026
Sexually dimorphic cannabinoid 1 receptors on CaMKIIα neurons in the medial pref [PMID:41380094]	Wang Q, Zhao J, Zhang X, Huang C, Li Y e	Pain	2026
A bioinspired anisotropic anti-inflammatory scaffold enhances spinal nerve regen [PMID:41737465]	Jiang M, Lu W, Zhuang J, Song J, Zhao Y	Mater Today Bio	2026
A multi-omics comparison unveils convergent and divergent antidepressant mechani [PMID:41796893]	Zhang J, Cai Y, Zhang P, Hao X, Guo B et	J Proteomics	2026