gene

SEMA3F

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SEMA3F: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

47Connections

0Hypotheses

0Analyses

36Outgoing

11Incoming

0Experiments

0Debates

Summary

Page for SEMA3F Gene

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🧬 Gene Info

Gene Symbol	SEMA3F
Full Name	Semaphorin 3F
Chromosome	3p21.31
Function	encodes a secreted axonal guidance molecule critical for neuronal development, synaptic organization, and vascular patterning.
Amino Acids	810 aa
Pathways	Amyloid, Epigenetic
UniProt ID	[Q13241](https://www.uniprot.org/uniprot/Q13241)
Ensembl ID	ENSG00000061656
GeneCards	SEMA3F
Human Protein Atlas	SEMA3F
Associated Diseases	neurodegeneration
Interactions	Actin, AMYLOID, APOE, APOE3, APOE4, App
KG Connections	47 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SEMA3F Gene

gene · 936 words

→

Pathway Diagram

graph TD
    SEMA3F["SEMA3F"]
    NRP1["NRP1"]
    SEMA3F -->|"binds"| NRP1
    NRP2["NRP2"]
    SEMA3F -->|"binds"| NRP2
    PI3K_Akt_mTOR["PI3K-Akt-mTOR"]
    SEMA3F -.->|"inhibits"| PI3K_Akt_mTOR
    Neutrophils["Neutrophils"]
    SEMA3F -->|"upregulates"| Neutrophils
    Tumor_Suppression["Tumor Suppression"]
    SEMA3F -->|"participates_in"| Tumor_Suppression
    Tumor_Angiogenesis["Tumor Angiogenesis"]
    SEMA3F -.->|"inhibits"| Tumor_Angiogenesis
    style SEMA3F fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (36)

Target	Relation	Type	Str
Tumor Suppression	participates_in	process	0.80
Tumor Angiogenesis	inhibits	process	0.80
Tumor Metastasis	inhibits	process	0.80
PI3K-Akt-mTOR	inhibits	pathway	0.80
Neutrophils	upregulates	cell_type	0.80
mTOR Signaling	inhibits	pathway	0.80
Lung Cancer	downregulates	disease	0.70
ERK1/2	downregulates	protein	0.70
AKT	downregulates	protein	0.70
STAT3	downregulates	protein	0.70
HIF-1alpha	downregulates	protein	0.70
VEGF	downregulates	protein	0.70
Neurodegeneration	activates	disease	0.65
Aβ	activates	protein	0.60
App	activates	protein	0.60
Wnt	associated_with	pathway	0.60
Stem Cell	activates	cell_type	0.60
Neuron	activates	cell_type	0.60
Epigenetic	activates	pathway	0.60
WNT	expressed_in	gene	0.60
DENDRITE	activates	gene	0.60
APOE3	activates	gene	0.60
Actin	activates	protein	0.60
Wnt	expressed_in	pathway	0.60
AMYLOID	activates	gene	0.60
Amyloid	activates	pathway	0.60
RNA	associated_with	gene	0.60
APOE4	activates	gene	0.60
LRP5	associated_with	gene	0.60
LRP1	expressed_in	gene	0.60
Cortex	expressed_in	brain_region	0.55
Stem Cell	expressed_in	cell_type	0.55
Neuron	expressed_in	cell_type	0.55
WNT SIGNALING	expressed_in	concept	0.50
CHIP	expressed_in	protein	0.50
LRP5	expressed_in	gene	0.50

Incoming (11)

Source	Relation	Type	Str
AMYLOID	activates	gene	0.60
APOE3	activates	gene	0.60
WNT	associated_with	gene	0.60
DENDRITE	activates	gene	0.60
APOE4	activates	gene	0.60
APP	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
LRP5	associated_with	gene	0.60
APOE	activates	gene	0.60
LRP1	associated_with	gene	0.60
LRP1	expressed_in	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SEMA3F in their description or question text

No additional research found