gene

HRH3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HRH3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

13Connections

0Hypotheses

0Analyses

12Outgoing

1Incoming

0Experiments

0Debates

Summary

HRH3 is a gene implicated in neurodegeneration research. Key relationships include: activates, implicated in. Associated with Als, Ms. Connected to 14 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	HRH3
Full Name	Histamine Receptor H3
Chromosome	20q13.33
Function	HRH3 encodes the H3 histamine receptor.
Primary Expression	the brain and play roles in cognitive function, attention, and motor control
Pathways	Dna Methylation, Epigenetic
UniProt ID	[Q9Y5N1](https://www.uniprot.org/uniprotkb/Q9Y5N1/entry)
GeneCards	HRH3
Human Protein Atlas	HRH3
Associated Diseases	Narcolepsy, cognition, addiction
Interactions	ADRA1A, ADRA1B, DRD1, DRD2, GRIA1, GRIN1
KG Connections	13 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

HRH3 Gene

gene · 500 words

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Pathway Diagram

graph TD
    HRH3["HRH3"]
    Ms{"Ms"}
    HRH3 -->|"activates"| Ms
    Als{"Als"}
    HRH3 -->|"activates"| Als
    HCRTR2["HCRTR2"]
    HRH3 -->|"activates"| HCRTR2
    ADRA1B["ADRA1B"]
    HRH3 -->|"activates"| ADRA1B
    DRD1["DRD1"]
    HRH3 -->|"activates"| DRD1
    GRIA1["GRIA1"]
    HRH3 -->|"activates"| GRIA1
    ADRA1A["ADRA1A"]
    HRH3 -->|"activates"| ADRA1A
    HRH1["HRH1"]
    HRH3 -->|"activates"| HRH1
    GRIN1["GRIN1"]
    HRH3 -->|"activates"| GRIN1
    HCRTR1["HCRTR1"]
    HRH3 -->|"activates"| HCRTR1
    Epigenetic(["Epigenetic"])
    HRH3 -->|"activates"| Epigenetic
    Dna_Methylation(["Dna Methylation"])
    HRH3 -->|"activates"| Dna_Methylation
    DRD2["DRD2"]
    DRD2 -->|"activates"| HRH3
    style HRH3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (12)

Target	Relation	Type	Str
Ms	activates	disease	0.65
Als	activates	disease	0.65
Epigenetic	activates	pathway	0.60
Dna Methylation	activates	pathway	0.60
HCRTR2	activates	gene	0.60
ADRA1B	activates	gene	0.60
DRD1	activates	gene	0.60
GRIA1	activates	gene	0.60
ADRA1A	activates	gene	0.60
HRH1	activates	gene	0.60
GRIN1	activates	gene	0.60
HCRTR1	activates	gene	0.60

Incoming (1)

Source	Relation	Type	Str
DRD2	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity