gene

DRD1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DRD1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

301Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

DRD1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, therapeutic target. Associated with ALS, Als, Alzheimer. Connected to 103 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	DRD1
Full Name	Dopamine Receptor D1
Chromosome	5q35.2
Protein Type	Receptor
Function	The D1 receptor is a postsynaptic dopamine receptor that:
Primary Expression	Striatum, Cortex, Nucleus accumbens, Olfactory bulb
Pathways	MAPK
UniProt ID	P21709
NCBI Gene ID	1817
Ensembl ID	ENSG00000184845
GeneCards	DRD1
Human Protein Atlas	DRD1
Associated Diseases	Als, Alzheimer, Autism, Bipolar, Cancer
Interactions	ADRA1A, ADRA1B, AND, BDNF, CACNA1B, CACNA1H
KG Connections	301 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: DRD1 — AlphaFold P21709 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

DRD1 Gene

gene · 1227 words

→

Dopamine Receptor D1 (DRD1)

protein · 557 words

→

Pathway Diagram

graph TD
    DRD1["DRD1"]
    DRD1 -->|"activates"| Ms["Ms"]
    DRD1 -->|"activates"| Als["Als"]
    DRD1 -->|"regulates"| Inflammation["Inflammation"]
    DRD1 -->|"target for"| Alzheimer["Alzheimer"]
    DRD1 -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    DRD1 -->|"activates"| GRIA1["GRIA1"]
    DRD1 -->|"activates"| ADRA1A["ADRA1A"]
    DRD1 -->|"activates"| HRH1["HRH1"]
    DRD2["DRD2"] -->|"activates"| DRD1
    HRH3["HRH3"] -->|"activates"| DRD1
    HCRTR2["HCRTR2"] -->|"activates"| DRD1
    ADRA1B["ADRA1B"] -->|"activates"| DRD1
    CLN3["CLN3"] -->|"target for"| DRD1
    DMSO["DMSO"] -->|"target for"| DRD1
    ERK["ERK"] -->|"activates"| DRD1
    MICROGLIA["MICROGLIA"] -->|"regulates"| DRD1
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"target for"| DRD1
    ASTROCYTES["ASTROCYTES"] -->|"regulates"| DRD1

Outgoing (192)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:DRD1	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
NLRP3	expresses	gene	0.70
NEURONS	activates	cell_type	0.70
PDGF	expresses	gene	0.70
DRD2	expresses	gene	0.70
NOTCH	transports	gene	0.70
DRD2	activates	gene	0.70
NEURONS	expresses	cell_type	0.70
Schizophrenia	associated_with	disease	0.65
Als	associated_with	disease	0.65
Neuroinflammation	activates	disease	0.65
Inflammation	activates	disease	0.65
NEURON	contributes_to	cell_type	0.65
Depression	associated_with	disease	0.65
Bipolar	associated_with	disease	0.65
Ms	associated_with	disease	0.65
DRD2	associated_with	gene	0.65
Inflammation	associated_with	disease	0.65
Huntington	encodes	disease	0.65
Synucleinopathy	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Parkinson	associated_with	disease	0.65
Ms	activates	disease	0.65
Als	activates	disease	0.65
Inflammation	regulates	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Neuroinflammation	regulates	disease	0.65
Ms	therapeutic_target	disease	0.65
Huntington	associated_with	disease	0.65
Huntington	expressed_in	disease	0.65
Alzheimer	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Autism	associated_with	disease	0.65
Epigenetic	activates	pathway	0.60
PDLIM5	associated_with	gene	0.60
MTDNA	associated_with	gene	0.60
DNA	associated_with	gene	0.60
DISEASE-ASSOCIATED MICROGLIA	therapeutic_target	gene	0.60
RNA	expressed_in	gene	0.60
NEURON	interacts_with	gene	0.60
TAU	regulates	gene	0.60
Neuron	interacts_with	cell_type	0.60
ALZHEIMER	associated_with	gene	0.60
AND	associated_with	gene	0.60
DEPRESSION	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
Autophagy	associated_with	pathway	0.60

Incoming (109)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:DRD1	data_in	dataset_row	0.00
genes-drd1	documents	wiki_page	1.00
ds-83b31ef18d49	data_in	dataset	1.00
genes-drd1	describes	wiki_page	1.00
DBH	transports	gene	0.70
BDNF	expressed_in	gene	0.70
NEUROINFLAMMATION	treats	phenotype	0.70
CACNA1B	interacts_with	gene	0.60
COMT	associated_with	gene	0.60
DDC	associated_with	gene	0.60
DNA	associated_with	gene	0.60
DEPRESSION	associated_with	gene	0.60
DISEASE-ASSOCIATED MICROGLIA	therapeutic_target	gene	0.60
DRD2	inhibits	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
AND	regulates	gene	0.60
HUNTINGTON	encodes	gene	0.60
RAS	therapeutic_target	gene	0.60
TCF4	expressed_in	gene	0.60
DRD2	interacts_with	gene	0.60
CACNA1H	associated_with	gene	0.60
CXCL10	therapeutic_target	gene	0.60
C1QA	therapeutic_target	gene	0.60
TAU	regulates	gene	0.60
GRM3	associated_with	gene	0.60
GABRA5	associated_with	gene	0.60
TPH2	associated_with	gene	0.60
CLN3	therapeutic_target	gene	0.60
NLRP3	activates	gene	0.60
NLRP3	therapeutic_target	gene	0.60
CX3CR1	therapeutic_target	gene	0.60
GPNMB	therapeutic_target	gene	0.60
P2RY12	therapeutic_target	gene	0.60
POLG	associated_with	gene	0.60
BMAL1	associated_with	gene	0.60
GABRB2	associated_with	gene	0.60
SLC1A1	associated_with	gene	0.60
SLC6A2	associated_with	gene	0.60
GRIK4	associated_with	gene	0.60
GRIA1	associated_with	gene	0.60
CACNA1B	associated_with	gene	0.60
FKBP5	associated_with	gene	0.60
NRG1	associated_with	gene	0.60
DAO	associated_with	gene	0.60
ESRRG	inhibits	gene	0.60
DMSO	therapeutic_target	gene	0.60
ERK	activates	gene	0.60
MICROGLIA	regulates	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
ASTROCYTES	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DRD1 in their description or question text

No additional research found