Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about JUND: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
JUND is a gene implicated in neurodegeneration research. Key relationships include: activates, therapeutic target, inhibits. Associated with Als, Leukemia, Ms. Connected to 23 entities in the SciDEX knowledge graph.
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| Gene Symbol | JUND |
| Full Name | JUND - JunD Transcription Factor |
| Aliases | Page for JUND Gene |
| Chromosome | 19p13.2 |
| Protein Type | Gene |
| Function | is a basic leucine zipper (bZIP) transcription factor that regulates genes involved in cell proliferation, differentiation, stress response, and apoptosis[@angel1991][@shaulian2002]. |
| Amino Acids | 347 aa |
| GeneCards | JUND |
| Human Protein Atlas | JUND |
| Associated Diseases | neurodegeneration |
| Interactions | CAT, C-FOS, C-JUN, EPO, FOS, GFAP |
| KG Connections | 22 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
JUND["JUND"]
Als{"Als"}
JUND -->|"expressed in"| Als
Leukemia{"Leukemia"}
JUND -->|"activates"| Leukemia
Tumor{"Tumor"}
JUND -->|"interacts with"| Tumor
Ms{"Ms"}
JUND -->|"inhibits"| Ms
C_JUN["C-JUN"]
JUND -->|"activates"| C_JUN
JUN["JUN"]
JUND -->|"activates"| JUN
GFAP["GFAP"]
JUND -->|"interacts with"| GFAP
CIRCADIAN_RHYTHM["CIRCADIAN RHYTHM"]
JUND -->|"therapeutic target"| CIRCADIAN_RHYTHM
JUND -->|"inhibits"| JUN
Akt(["Akt"])
JUND -->|"therapeutic target"| Akt
Circadian_Rhythm(["Circadian Rhythm"])
JUND -->|"therapeutic target"| Circadian_Rhythm
Pi3K(["Pi3K"])
JUND -->|"therapeutic target"| Pi3K
FOS["FOS"]
FOS -->|"activates"| JUND
EPO["EPO"]
EPO -->|"activates"| JUND
C_FOS["C-FOS"]
C_FOS -->|"activates"| JUND
CAT["CAT"]
CAT -->|"activates"| JUND
FOS -->|"inhibits"| JUND
PI3K["PI3K"]
PI3K -->|"therapeutic target"| JUND
RELA["RELA"]
RELA -->|"inhibits"| JUND
MYC["MYC"]
MYC -->|"inhibits"| JUND
AKT["AKT"]
AKT -->|"therapeutic target"| JUND
KLF4["KLF4"]
KLF4 -->|"inhibits"| JUND
style JUND fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Ms | inhibits | disease | 0.65 |
| Leukemia | activates | disease | 0.65 |
| Tumor | interacts_with | disease | 0.65 |
| Als | expressed_in | disease | 0.65 |
| C-JUN | activates | gene | 0.60 |
| Pi3K | therapeutic_target | pathway | 0.60 |
| CIRCADIAN RHYTHM | therapeutic_target | gene | 0.60 |
| Akt | therapeutic_target | pathway | 0.60 |
| Circadian Rhythm | therapeutic_target | pathway | 0.60 |
| JUN | activates | gene | 0.60 |
| JUN | inhibits | gene | 0.60 |
| GFAP | interacts_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning JUND in their description or question text
No additional research found