gene 1,761 words KG: ARNT2
Contents

ARNT2 - Aryl Hydrocarbon Receptor Nuclear Translocator 2

🧬 Gene Info
Gene SymbolARNT2
Full NameAryl Hydrocarbon Receptor Nuclear Translocator 2
AliasesARNT2 gene
Chromosome15q21.3
Functionencodes a critical bHLH-PAS (basic Helix-Loop-Helix-Period Arnt-Single-minded) domain transcription factor that serves as a shared partner for multiple hypoxia-sensitive and circadian rhythm regula...
Molecular Weight79 kDa
Amino Acids710 aa
Exons24
UniProt IDQ9W2E6
NCBI Gene ID10638
Ensembl IDENSG00000150457
OMIM606994
GeneCardsARNT2
Human Protein AtlasARNT2
bHLH Domain (aa 1-60)Basic region for DNA binding and helix-loop-helix for protein dimerization
Associated Diseasesneurodegeneration
InteractionsACC, SST
KG Connections25 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (10)

Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.90
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.86
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Circadian Clock-Autophagy Synchronization
Score: 0.76
Circadian-Synchronized Proteostasis Enhancement
Score: 0.74
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65
TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Score: 0.62
Temporal Decoupling via Circadian Clock Reset
Score: 0.54

Related Analyses (4)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (11)

acc-chronic-pain
cell_type · KG edge: inhibits
NeuRon Therapeutics
company · KG edge: expressed_in
Apoptosis in Neurodegeneration
entity · KG edge: therapeutic_target
MITF Gene — Microphthalmia-Associated Transcription Fac
gene · KG edge: transports
NCOR1 Gene - Nuclear Receptor Corepressor 1
gene · KG edge: transports

Knowledge Graph (12 edges)

ARNT2 expressed_in SST
SST activates ARNT2
ARNT2 activates Pyramidal
ARNT2 activates SST
ARNT2 expressed_in Pyramidal Cell
ARNT2 regulates Rb
ARNT2 transports NCOR1
ARNT2 transports TCF7L2
ARNT2 transports MITF
ACC inhibits ARNT2

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