| Gene Symbol | AIFM3 |
| Full Name | Apoptosis-Inducing Factor Mitochondria 3 |
| Chromosome | 22q13.33 |
| Function | is a mitochondrial protein homologous to AIFM1 and AIFM2, involved in apoptosis and cell death pathways. |
| Primary Expression | various tissues, with notable expression in: - Heart and skeletal muscle (high mitochondrial content) - Brain regions including [cortex](/brain-region |
| Subcellular Localization | mitochondria, with potential for translocation under certain conditions |
| GeneCards | AIFM3 |
| Human Protein Atlas | AIFM3 |
| FAD-binding domain | Contains flavin adenine dinucleotide (FAD)-binding capacity, suggesting oxidoreductase activity [@miranville2004] |
| NADH-binding domain | Involved in electron transfer reactions |
| C-terminal domain | Mediates interactions with other proteins and DNA |
| Apoptosis Effector | Mediates caspase-independent cell death pathways, though its pro-apoptotic activity appears weaker than AIFM1 [@susin2000] |
| Oxidoreductase | Has NADH oxidase activity, potentially involved in mitochondrial electron transport |
| Mitochondrial Localization | Primarily localized to mitochondria, with potential for translocation under certain conditions |
| Associated Diseases | neurodegeneration may lead to therapeutic strategies targeting mito |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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