| Gene Symbol | AIFM1 |
| Aliases | AIFM1PROTEIN |
| Function | encodes a crucial flavoprotein that plays dual roles in both normal mitochondrial function and programmed cell death. |
| Subcellular Localization | </th><td>Inner mitochondrial membrane (mature form); nucleus (during apoptosis)</td></tr> |
| Molecular Weight | 63 kDa |
| Amino Acids | 613 aa |
| Pathways | Apoptosis, Mapk, Wnt signaling, apoptosis pathway, MAPK signaling |
| Ensembl ID | ENSG00000156509 |
| GeneCards | AIFM1 |
| Human Protein Atlas | AIFM1 |
| FAD-binding domain | Comprises residues 150-400 and binds FAD cofactor essential for NADH oxidase activity |
| DNA-binding domain | C-terminal region (residues 400-613) can bind DNA in the nucleus during apoptosis |
| Proline-rich region | Contains SH3-binding motifs for protein-protein interactions |
| Associated Diseases | ALS |
| Interactions | ALZHEIMER, AND, APOPTOSIS, ATP, ATP5A1, CALCOCO2 |
| KG Connections | 98 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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