| Gene Symbol | AIF |
| Chromosome | Xq26.1 |
| Protein Type | Gene |
| Function | AIF is required for the proper assembly and stability of Complex I, the largest enzyme complex in the electron transport chain.[@ghezzi2010][@klein2002] AIF-deficient cells show 50–70% reduction in Co |
| Molecular Weight | 67 kDa |
| Pathways | Apoptosis, Ferroptosis, Inflammasome, Necroptosis, Oxidative Stress |
| GeneCards | AIF |
| Human Protein Atlas | AIF |
| FAD-binding domain | Binds flavin adenine dinucleotide (FAD) as a cofactor, conferring NADH oxidase activity essential for mitochondrial respiratory chain function.[@mate2002] |
| NADH-binding domain | Catalyzes NADH-dependent electron transfer. The oxidoreductase activity is critical for proper assembly and maintenance of Complex I (NADH:ubiquinone oxidoreductase).[@mate2002][@ghezzi2010] |
| Associated Diseases | ALS, Alzheimer, Inflammation, Ms, Neurodegeneration, Neuroinflammation |
| Interactions | AKT, ALS, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK, AMYOTROPHIC LATERAL SCLEROSIS |
| KG Connections | 232 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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