concept

PGRN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PGRN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

206Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	PGRN
Key Genes/Proteins	ABCA1, Adiponectin, AGING, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID
Related Diseases	Aging, Als, ALS, Alzheimer, Alzheimer's disease
Related Pathways	Amyloid

Wiki Pages (3)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    PGRN["PGRN"]
    style PGRN fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    PGRN -.->|"biomarker for"| Fibrosis["Fibrosis"]
    PGRN -.->|"biomarker for"| ALS["ALS"]
    PGRN -.->|"biomarker for"| Aging["Aging"]
    PGRN -.->|"biomarker for"| Inflammation["Inflammation"]
    PGRN -.->|"biomarker for"| Senescence["Senescence"]
    PGRN -.->|"biomarker for"| Als["Als"]
    PGRN -->|"causes"| Dementia["Dementia"]
    PGRN -->|"causes"| Neurodegeneration["Neurodegeneration"]
    PGRN -->|"expressed in"| Alzheimer["Alzheimer"]
    IGF_1([IGF-1]) -.->|"biomarker for"| PGRN
    MITOCHONDRIA([MITOCHONDRIA]) -.->|"biomarker for"| PGRN
    FGF21([FGF21]) -->|"activates"| PGRN
    GPNMB([GPNMB]) -.->|"biomarker for"| PGRN
    VIMENTIN([VIMENTIN]) -->|"activates"| PGRN
    AMYLOID([AMYLOID]) -.->|"biomarker for"| PGRN
    VIM([VIM]) -->|"activates"| PGRN
    HMGB1([HMGB1]) -.->|"biomarker for"| PGRN
    S100B([S100B]) -.->|"biomarker for"| PGRN
    C1Q([C1Q]) -.->|"biomarker for"| PGRN

Outgoing (126)

Target	Relation	Type	Str
Frailty	biomarker_for	phenotype	0.95
Parkinson's disease	associated_with	disease	0.80
amyotrophic lateral sclerosis	exacerbates	disease	0.80
neurons	regulates	cell_type	0.80
microglia	regulates	cell_type	0.80
limbic-predominant age-related transactivation response DNA-binding protein 43 encephalopathy	associated_with	disease	0.80
frontotemporal dementia	associated_with	disease	0.80
Alzheimer's disease	associated_with	disease	0.80
oxidative stress response	participates_in	pathway	0.70
frontotemporal dementia	causes	disease	0.70
TRAUMATIC BRAIN INJURY	markers	disease	0.70
stem cells	expressed_in	cell_type	0.70
neurodegeneration	protects_against	disease	0.70
neurodegeneration	regulates	disease	0.70
TAR	interacts_with	gene	0.70
neurons	expressed_in	cell_type	0.70
neurodegeneration	associated_with	disease	0.70
Neurodegeneration	causes	disease	0.65
Als	causes	disease	0.65
Dementia	causes	disease	0.65
Traumatic Brain Injury	associated_with	disease	0.65
ALS	biomarker_for	disease	0.65
Fibrosis	biomarker_for	disease	0.65
Aging	biomarker_for	disease	0.65
Inflammation	biomarker_for	disease	0.65
Senescence	biomarker_for	disease	0.65
ALS	causes	disease	0.65
Frontotemporal Dementia	causes	disease	0.65
Als	biomarker_for	disease	0.65
Alzheimer	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Amyotrophic Lateral Sclerosis	expressed_in	disease	0.65
frontotemporal dementia	targets	disease	0.60
macrophages	expressed_in	cell_type	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
neuroinflammation	regulates	disease	0.60
TMEM106B	activates	gene	0.60
neurodegeneration	interacts_with	disease	0.60
oligodendrocytes	expressed_in	cell_type	0.60
RNA	associated_with	gene	0.60
neuroinflammation	activates	disease	0.60
lipid metabolism	participates_in	pathway	0.60
frontotemporal dementia	regulates	disease	0.60
SQSTM1	regulates	gene	0.60
IL-6	activates	gene	0.60
S100B	biomarker_for	gene	0.60
AMYLOID	biomarker_for	gene	0.60
FNDC5	activates	gene	0.60
BDNF	activates	gene	0.60
IGF-1	biomarker_for	gene	0.60

Incoming (80)

Source	Relation	Type	Str
GRN	activates	gene	0.60
KL	activates	gene	0.60
FTLD	interacts_with	gene	0.60
GRN	interacts_with	gene	0.60
APP	associated_with	gene	0.60
APP	activates	gene	0.60
BRD4	activates	gene	0.60
BMP	activates	gene	0.60
BMP	associated_with	gene	0.60
FTLD	protects_against	gene	0.60
GRN	protects_against	gene	0.60
AXL	regulates	gene	0.60
GRN	regulates	gene	0.60
MERTK	regulates	gene	0.60
ABCA1	regulates	gene	0.60
APOE	regulates	gene	0.60
CTSB	regulates	gene	0.60
CTSH	regulates	gene	0.60
FCER1G	regulates	gene	0.60
HLA	regulates	gene	0.60
MARCKS	regulates	gene	0.60
LRP1	interacts_with	gene	0.60
30283395	elevated in	paper	0.60
30283395	normalized at follow up in	paper	0.60
NEURODEGENERATION	causes	gene	0.60
GRN	causes	gene	0.60
PROGRANULIN	causes	gene	0.60
NESTIN	expressed_in	gene	0.60
BRAIN INJURY	associated_with	gene	0.60
COMPLEMENT	biomarker_for	gene	0.60
CX3CL1	activates	gene	0.60
APOPTOSIS	biomarker_for	gene	0.60
GHRL	biomarker_for	gene	0.60
GRN	inhibits	gene	0.60
AND	activates	gene	0.60
IGF-1	biomarker_for	gene	0.60
MITOCHONDRIA	biomarker_for	gene	0.60
FGF21	activates	gene	0.60
GPNMB	biomarker_for	gene	0.60
VIMENTIN	activates	gene	0.60
AMYLOID	biomarker_for	gene	0.60
VIM	activates	gene	0.60
HMGB1	biomarker_for	gene	0.60
S100B	biomarker_for	gene	0.60
C1Q	biomarker_for	gene	0.60
FNDC5	activates	gene	0.60
FGF23	activates	gene	0.60
IL-6	activates	gene	0.60
CXCL10	activates	gene	0.60
AGING	biomarker_for	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PGRN in their description or question text

No additional research found