| Gene Symbol | GRN |
| Full Name | Progranulin |
| Aliases | PROGRANULIN_PROTEIN |
| Function | is a secreted glycoprotein encoded by the GRN gene that functions as a crucial regulator of neuronal survival, lysosomal function, immune response, and synaptic plasticity. |
| Primary Expression | Neurons, Microglia, Macrophages, Epithelial cells |
| Subcellular Localization | Secreted, Lysosomes, Cytoplasm |
| Molecular Weight | 63.5 kDa (full-length); secreted fragments: 6-25 kDa |
| Amino Acids | 593 aa |
| UniProt ID | P28799 |
| GeneCards | GRN |
| Human Protein Atlas | GRN |
| P-granulin (full-length) | Contains all 7.5 repeats |
| Granulin A-G | Individual repeats released by proteolytic cleavage |
| Paragranulin | Contains only the first four repeats |
| Associated Diseases | Frontotemporal Dementia, Amyotrophic Lateral Sclerosis, Alzheimer's Disease |
| Databases | GeneCardsNCBI GeneHPASTRING |
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