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protein 1,536 words KG: PROGRANULIN
Contents

Progranulin (PGRN)

🔬 Protein Info
Gene SymbolGRN
AliasesPROGRANULIN
Protein FamilyProgranulin family
Functionis a secreted glycoprotein encoded by the <a href="/genes/grn">GRN</a> gene that functions as a crucial regulator of neuronal survival, lysosomal function, and immune response[@baker2006].
Primary ExpressionSecreted, Lysosomes, Cytoplasm
Subcellular LocalizationSecreted, Lysosomes, Cytoplasm
Molecular Weight90 kDa
Amino Acids60 aa
PathwaysImmune Response, Inflammasome, Tdp-43, Toll-Like Receptor, inflammation
UniProt IDP28799
GeneCardsGRN
Human Protein AtlasGRN
Associated DiseasesAls, Dementia, disease, Frontotemporal Dementia
InteractionsActin, AGING, ALZHEIMER, AMYOTROPHIC LATERAL SCLEROSIS, AND, APOE
KG Connections324 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (30)

TREM2-Dependent Microglial Senescence Transition
Score: 0.95Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.92APOE-Dependent Autophagy Restoration
Score: 0.85Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79

Related Analyses (12)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archivedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedAstrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archivedBlood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived

Related Experiments (3)

Presymptomatic GRN Carrier Intervention Timing — Biomarker-G
clinical · proposed · Score: 0.40Progranulin Replacement Therapy for FTD — Vector Development
clinical · proposed · Score: 0.40Mechanism: Progranulin Loss and TDP-43 Pathology in FTD
validation · proposed · Score: 0.40

See Also (10)

Amyotrophic Lateral Sclerosis
redirect · KG edge: activatesApoptosis in Neurodegeneration
entity · KG edge: biomarker_forAmyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: biomarker_forAstrocytes
entity · KG edge: activatesAQP4 (Aquaporin-4 Gene)
gene · KG edge: activates

Knowledge Graph (12 edges)

TREM2 activates PROGRANULIN
PROGRANULIN activates CX3CR1
GPNMB biomarker_for PROGRANULIN
CX3CL1 activates PROGRANULIN
PROGRANULIN biomarker_for APP
PROGRANULIN activates CXCL10
PROGRANULIN activates BDNF
PROGRANULIN activates FGF23
PROGRANULIN activates PLAU
PROGRANULIN activates VIM

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