| Gene Symbol | GRN |
| Aliases | PROGRANULIN |
| Chromosome | 17q21.31 |
| Protein Family | Progranulin family |
| Function | is a secreted glycoprotein encoded by the <a href="/genes/grn">GRN</a> gene that functions as a crucial regulator of neuronal survival, lysosomal function, and immune response[@baker2006]. |
| Primary Expression | Secreted, Lysosomes, Cytoplasm |
| Subcellular Localization | Secreted, Lysosomes, Cytoplasm |
| Molecular Weight | 90 kDa |
| Amino Acids | 60 aa |
| Pathways | Immune Response, Inflammasome, Tdp-43, Toll-Like Receptor, inflammation |
| UniProt ID | P28799 |
| GeneCards | GRN |
| Human Protein Atlas | GRN |
| Gene | GRN (Progranulin) located on chromosome 17q21.31 |
| Protein | Progranulin, 593 amino acids (~63 kDa) |
| Associated Diseases | Als, Dementia, disease, Frontotemporal Dementia |
| Interactions | Actin, AGING, ALZHEIMER, AMYOTROPHIC LATERAL SCLEROSIS, AND, APOE |
| KG Connections | 319 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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