protein

OCCLUDIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about OCCLUDIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

99Connections

0Hypotheses

1Analyses

41Outgoing

50Incoming

0Experiments

1Debates

Summary

Page for Occludin Protein

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🔬 Protein Info

Gene Symbol	OCCLUDIN
Molecular Weight	65.4 kDa
Amino Acids	522 aa
Pathways	TIGHT_JUNCTION
GeneCards	OCCLUDIN
Human Protein Atlas	OCCLUDIN
Interactions	ACTB, ALZHEIMER, APP, ATG14, BECN1, CASP3
KG Connections	91 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    OCCLUDIN["OCCLUDIN"]
    TIGHT_JUNCTION["TIGHT_JUNCTION"]
    OCCLUDIN -->|"participates_in"| TIGHT_JUNCTION
    ENDOTHELIAL_CELLS["ENDOTHELIAL_CELLS"]
    OCCLUDIN -->|"expressed_in"| ENDOTHELIAL_CELLS
    EPITHELIAL_CELLS["EPITHELIAL_CELLS"]
    OCCLUDIN -->|"expressed_in"| EPITHELIAL_CELLS
    MLCK(["MLCK"])
    OCCLUDIN -->|"activates"| MLCK
    OCLN(["OCLN"])
    OCCLUDIN -->|"co_discussed"| OCLN
    PPAR(["PPAR"])
    OCCLUDIN -->|"activates"| PPAR
    IL_6(["IL-6"])
    IL_6 -->|"activates"| OCCLUDIN
    TNF(["TNF"])
    TNF -->|"activates"| OCCLUDIN
    ALZHEIMER(["ALZHEIMER"])
    ALZHEIMER -->|"activates"| OCCLUDIN
    style OCCLUDIN fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#4fc3f7

Outgoing (41)

Target	Relation	Type	Str
Intestinal Barrier Function	involved_in	phenotype	0.80
BBB_integrity	maintains	pathway	0.80
TIGHT_JUNCTION	participates_in	pathway	0.72
ENDOTHELIAL_CELLS	expressed_in	cell_type	0.64
EPITHELIAL_CELLS	expressed_in	cell_type	0.64
inflammation	activates	pathway	0.50
COPD	activates	disease	0.50
Proteins	activates	protein	0.50
Microrna	activates	pathway	0.50
ENDOTHELIAL	interacts_with	concept	0.50
inflammation	regulates	pathway	0.50
CEREBELLUM	activates	concept	0.50
IL-17	activates	concept	0.50
DIABETES	inhibits	disease	0.50
ANGPT1	inhibits	concept	0.50
TNF-α	activates	concept	0.50
TUMOR	regulates	disease	0.50
TNF-α	regulates	concept	0.50
CDH1	inhibits	concept	0.50
Ubiquitin-Proteasome	activates	pathway	0.50
Cerebrovascular	activates	pathway	0.50
Endothelial Cell	activates	cell_type	0.50
disease	activates	disease	0.50
TJP1	activates	concept	0.50
ENDOTHELIAL	activates	concept	0.50
TUBULIN	activates	protein	0.50
Stem Cell	activates	cell_type	0.50
SCIN	activates	concept	0.50
Cell Division	activates	pathway	0.50
MLCK	activates	gene	0.50
OCLN	co_discussed	gene	0.50
PPAR	activates	protein	0.50
STROKE	co_discussed	gene	0.50
Receptor Tyrosine Kinase	activates	pathway	0.50
CLDN1	activates	concept	0.50
BCL-2	expressed_in	protein	0.50
Proteins	expressed_in	protein	0.50
Proteins	associated_with	protein	0.50
apoptosis	activates	process	0.50
Hippocampus	inhibits	entity	0.50
GENE EXPRESSION	inhibits	concept	0.50

Incoming (58)

Source	Relation	Type	Str
OCLN	encodes	gene	0.95
CSD	activates	drug	0.80
SLC26A3	regulates	gene	0.80
L. reuteri-CMVs	activates	drug	0.80
propionate	activates	drug	0.80
OCLN	encodes	gene	0.80
CUGBP1	regulates	protein	0.70
BECN1	activates	gene	0.50
UBIQUITIN	activates	protein	0.50
CLAUDIN-5	expressed_in	protein	0.50
ACTB	activates	gene	0.50
ATG14	activates	gene	0.50
H2AX	activates	gene	0.50
UVRAG	activates	gene	0.50
SQSTM1	activates	gene	0.50
STK11	activates	gene	0.50
MAP1LC3B	activates	gene	0.50
PIK3C3	activates	gene	0.50
GAPDH	activates	gene	0.50
CYP11A1	activates	gene	0.50
TUBB3	activates	gene	0.50
HDAC6	activates	gene	0.50
HIF1A	activates	gene	0.50
MAP3K5	activates	gene	0.50
CASP3	activates	gene	0.50
GJA1	activates	gene	0.50
VIMENTIN	activates	protein	0.50
LAMP1	activates	protein	0.50
RAC1	activates	protein	0.50
IL-1Β	activates	protein	0.50
PHAGOCYTOSIS	activates	gene	0.50
LRP1	activates	gene	0.50
CLAUDIN-5	activates	protein	0.50
CLAUDIN-5	inhibits	protein	0.50
MLCK	activates	gene	0.50
NADPH	activates	protein	0.50
CLAUDIN-5	associated_with	protein	0.50
CDC42	activates	gene	0.50
Autophagy	activates	process	0.50
OCLN	activates	gene	0.50
CAV1	activates	gene	0.50
CLDN5	activates	gene	0.50
IL-6	activates	protein	0.50
TNF	activates	gene	0.50
ALZHEIMER	activates	gene	0.50
APP	activates	gene	0.50
CLAUDIN-5	co_discussed	protein	0.50
GENES	co_discussed	gene	0.50
LRP1	co_discussed	gene	0.50
BMAL1	regulates	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Blood-brain barrier transport mechanisms for antibody therapeutics

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.773

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Anti-amyloid antibodies (lecanemab, donanemab) have ~0.1% brain penetrance. Engi

closed · Rounds: 4 · Score: 0.91 · 2026-04-06