gene

MCC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MCC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

134Connections

0Hypotheses

0Analyses

50Outgoing

45Incoming

0Experiments

0Debates

Summary

MCC is a gene implicated in neurodegeneration research. Key relationships include: associated with, expressed in, therapeutic target. Associated with Aging, Als, Cancer. Connected to 107 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	MCC
Chromosome	5q22.2
Function	encodes a protein of approximately 829 amino acids with a molecular weight of ~93 kDa.
Primary Expression	most tissues
Molecular Weight	93 kDa
Amino Acids	829 aa
Pathways	Akt, Apoptosis, Autophagy, Cholesterol, Ferroptosis
UniProt ID	P23508
NCBI Gene ID	6815
Ensembl ID	ENSG00000149691
GeneCards	MCC
Human Protein Atlas	MCC
LEU zipper	Potential leucine zipper for dimerization - mediates protein-protein interactions and may facilitate homodimerization or heterodimerization with related proteins
PDZ-binding motif	Mediates interactions with PDZ domain proteins - these interactions are crucial for anchoring MCC to cellular signaling complexes at the plasma membrane
Nuclear localization signals	Suggests potential nuclear function - MCC can translocate to the nucleus where it may influence transcriptional programs
Associated Diseases	Aging, Als, Alzheimer, Diabetes, Inflammation, Ms
Interactions	APOPTOSIS, AUTOPHAGY, BCL2, BECN1, PIK3C3
KG Connections	134 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: MCC — AlphaFold P23508 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

MCC Gene

gene · 1744 words

→

MCCC1 Gene

gene · 1829 words

→

Pathway Diagram

graph TD
    MCC["MCC"] -->|"expressed in"| Cancer["Cancer"]
    MCC["MCC"] -->|"regulates"| Ms["Ms"]
    MCC["MCC"] -->|"activates"| Tumor["Tumor"]
    MCC["MCC"] -->|"expressed in"| Carcinoma["Carcinoma"]
    MCC["MCC"] -->|"therapeutic target"| Als["Als"]
    MCC["MCC"] -->|"therapeutic target"| Ms_1["Ms"]
    PIK3C3["PIK3C3"] -.->|"inhibits"| MCC["MCC"]
    APP["APP"] -->|"therapeutic target"| MCC["MCC"]
    AGING["AGING"] -->|"associated"| MCC["MCC"]
    IL6["IL6"] -->|"associated"| MCC["MCC"]
    style MCC fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (89)

Target	Relation	Type	Str
Fibrosis	expressed_in	disease	0.65
Als	therapeutic_target	disease	0.65
Ms	expressed_in	disease	0.65
Carcinoma	biomarker_for	disease	0.65
Tumor	biomarker_for	disease	0.65
Ms	therapeutic_target	disease	0.65
Diabetes	associated_with	disease	0.65
Als	associated_with	disease	0.65
Ms	interacts_with	disease	0.65
Hepatitis	therapeutic_target	disease	0.65
Ms	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Senescence	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Ms	regulates	disease	0.65
Tumor	activates	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Carcinoma	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Alzheimer	associated_with	disease	0.65
KIF11	expressed_in	gene	0.60
RAGE	expressed_in	gene	0.60
AUTOPHAGY	expressed_in	gene	0.60
Autophagy	expressed_in	pathway	0.60
Glycolysis	expressed_in	pathway	0.60
Akt	expressed_in	pathway	0.60
Nf-Κb	expressed_in	pathway	0.60
Pi3K	expressed_in	pathway	0.60
TAU PATHOLOGY	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
AMYLOID	associated_with	gene	0.60
Amyloid	associated_with	pathway	0.60
NDUFAF1	associated_with	gene	0.60
Aβ	therapeutic_target	protein	0.60
SLC7A11	therapeutic_target	gene	0.60
STAT6	associated_with	gene	0.60
SPP1	therapeutic_target	gene	0.60
SLC7A11	associated_with	gene	0.60
Ferroptosis	therapeutic_target	pathway	0.60
Autophagy	therapeutic_target	pathway	0.60
Immune Response	therapeutic_target	pathway	0.60
MITOCHONDRIAL DYSFUNCTION	associated_with	gene	0.60
IMMUNE INFILTRATION	associated_with	gene	0.60
APOPTOSIS	associated_with	gene	0.60
DIABETIC RETINOPATHY	associated_with	gene	0.60
Apoptosis	associated_with	pathway	0.60
Mitochondrial Function	associated_with	pathway	0.60
Immune Response	associated_with	pathway	0.60

Incoming (45)

Source	Relation	Type	Str
GNAL	expressed_in	gene	0.60
VAMP7	expressed_in	gene	0.60
MMP9	expressed_in	gene	0.60
PI3K	expressed_in	gene	0.60
AKT	expressed_in	gene	0.60
AKT1	expressed_in	gene	0.60
APOE4	associated_with	gene	0.60
APOA2	associated_with	gene	0.60
APOC2	associated_with	gene	0.60
NDUFAF1	associated_with	gene	0.60
MIRNAS	therapeutic_target	gene	0.60
G6PD	therapeutic_target	gene	0.60
CYTOKINES	associated_with	gene	0.60
APOPTOSIS	inhibits	gene	0.60
CANCER	expressed_in	gene	0.60
GENES	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
APP	therapeutic_target	gene	0.60
IL6	associated_with	gene	0.60
MMP9	associated_with	gene	0.60
TP53	associated_with	gene	0.60
TAU	therapeutic_target	gene	0.60
AGING	therapeutic_target	gene	0.60
ACSL4	therapeutic_target	gene	0.60
FOXP3	associated_with	gene	0.60
HMOX1	therapeutic_target	gene	0.60
IGF1	therapeutic_target	gene	0.60
KIF20A	therapeutic_target	gene	0.60
MYC	associated_with	gene	0.60
BECN1	inhibits	gene	0.60
BCL2	inhibits	gene	0.60
AGING	associated_with	gene	0.60
P53	associated_with	gene	0.60
INFLAMMATION	associated_with	gene	0.60
ACOX1	associated_with	gene	0.60
BNIP3	associated_with	gene	0.60
MFN1	associated_with	gene	0.60
NDUFAF7	associated_with	gene	0.60
NBR1	associated_with	gene	0.60
NF-ΚB	expressed_in	gene	0.60
PIK3C3	inhibits	gene	0.60
IL1B	associated_with	gene	0.60
TNF	associated_with	gene	0.60
AMYLOID	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MCC in their description or question text

No additional research found