gene

JUN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about JUN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2436Connections

6Hypotheses

0Analyses

50Outgoing

50Incoming

5Experiments

0Debates

Summary

JUN is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, inhibits. Associated with ALS, Aging, Als. Connected to 1765 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	JUN
Full Name	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit
Chromosome	1p32.1
Protein Type	Transcription Factor
Function	c-Jun/AP-1 is a key transcription factor
Primary Expression	proliferating neural progenitors and migrating neurons, declining to lower basal levels in the adult brain
Pathways	Akt, Amyloid, Apoptosis, Autophagy, Blood-Brain Barrier
UniProt ID	P45985
NCBI Gene ID	3715
Ensembl ID	ENSG00000100994
OMIM	165160
GeneCards	JUN
Human Protein Atlas	JUN
Associated Diseases	Addiction, Aging, Als, Alzheimer, Autoimmune
Known Drugs/Compounds	anti-CD3, burn serum, pokeweed mitogen, quercetin
Interactions	ABCA1, ABCB1, ACSL5, ACTB, Actin, AGING
KG Connections	2436 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: JUN — AlphaFold P45985 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    JUN["JUN"] -->|"protects against"| Alzheimer["Alzheimer"]
    JUN["JUN"] -->|"regulates"| Schizophrenia["Schizophrenia"]
    JUN["JUN"] -->|"regulates"| Epilepsy["Epilepsy"]
    JUN["JUN"] -->|"regulates"| Alzheimer["Alzheimer"]
    JUN["JUN"] -->|"regulates"| Autism["Autism"]
    JUN["JUN"] -->|"regulates"| Depression["Depression"]
    JUN["JUN"] -->|"regulates"| Bipolar["Bipolar"]
    JUN["JUN"] -->|"regulates"| Ms["Ms"]
    JUN["JUN"] -.->|"inhibits"| Epilepsy["Epilepsy"]
    JUN["JUN"] -.->|"inhibits"| Ms["Ms"]
    JUN["JUN"] -.->|"inhibits"| Als["Als"]
    JUN["JUN"] -->|"therapeutic target"| Cancer["Cancer"]
    style JUN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0
    style Alzheimer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Schizophrenia fill:#ef5350,stroke:#333,color:#e0e0e0
    style Epilepsy fill:#ef5350,stroke:#333,color:#e0e0e0
    style Autism fill:#ef5350,stroke:#333,color:#e0e0e0
    style Depression fill:#ef5350,stroke:#333,color:#e0e0e0
    style Bipolar fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cancer fill:#ef5350,stroke:#333,color:#e0e0e0

Outgoing (1460)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:JUN	data_in	dataset_row	0.00
Als	activates	disease	1.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Als	therapeutic_target	disease	1.00
Cancer	therapeutic_target	disease	1.00
Apoptosis	activates	pathway	1.00
Inflammation	activates	disease	1.00
Tumor	therapeutic_target	disease	1.00
Tumor	activates	disease	1.00
PARKINSON'S DISEASE	associated_with	gene	1.00
NEURODEGENERATION	associated_with	gene	1.00
Neurodegeneration	activates	disease	1.00
Inflammation	regulates	disease	1.00
GENES	therapeutic_target	gene	1.00
Cancer	inhibits	disease	0.95
Inflammation	therapeutic_target	disease	0.95
Neuroinflammation	activates	disease	0.95
Cancer	activates	disease	0.95
CDK2	inhibits	gene	0.90
neoplastic transformation	causes	phenotype	0.90
cell division	inhibits	phenotype	0.90
AP-1	component_of	protein	0.90
cell proliferation	inhibits	phenotype	0.90
CCNA	inhibits	gene	0.90
DNA synthesis	inhibits	phenotype	0.90
HDAC7	activates	protein	0.90
G0/G1 phase arrest	causes	phenotype	0.90
CCNE	inhibits	gene	0.90
HDAC7	associated_with	gene	0.90
endoreplication	inhibits	phenotype	0.90
fibrosarcomas	causes	disease	0.90
DEPRESSION	associated_with	gene	0.90
MTOR	associated_with	gene	0.90
MICROGLIA	associated_with	gene	0.90
Mapk	therapeutic_target	pathway	0.90
Mapk	activates	pathway	0.90
Apoptosis	therapeutic_target	pathway	0.90
Oxidative Stress	activates	pathway	0.90
C-JUN	activates	gene	0.90
Ferroptosis	inhibits	pathway	0.90
Parkinson	regulates	disease	0.85
Als	regulates	disease	0.85
Inflammation	inhibits	disease	0.85
Alzheimer	regulates	disease	0.85
Neurodegeneration	therapeutic_target	disease	0.85
PD-L1	interacts_with	protein	0.85
Parkinson	activates	disease	0.85
Ischemia	activates	disease	0.85
Neurodegeneration	regulates	disease	0.85
Cancer	associated_with	disease	0.85

Incoming (976)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:JUN	data_in	dataset_row	0.00
P38	activates	gene	1.00
ALZHEIMER'S DISEASE	associated_with	gene	1.00
C-JUN	activates	gene	1.00
JNK	activates	gene	1.00
genes-jun	documents	wiki_page	1.00
ROS	activates	gene	1.00
ds-83b31ef18d49	data_in	dataset	1.00
TNF	activates	gene	1.00
GENES	activates	gene	1.00
C-JUN	regulates	gene	1.00
JNK	inhibits	gene	1.00
pokeweed mitogen	activates	drug	0.90
anti-CD3	activates	drug	0.90
genes-jun	describes	wiki	0.90
AUTOPHAGY	associated_with	gene	0.90
AP-1	regulates	protein	0.90
AMYLOID	associated_with	gene	0.90
C-JUN	associated_with	gene	0.90
CANCER	therapeutic_target	gene	0.90
AKT1	targets	gene	0.90
BCL-2	activates	gene	0.90
TNF	therapeutic_target	gene	0.90
PI3K	therapeutic_target	gene	0.90
C-JUN	inhibits	gene	0.90
NEURODEGENERATION	activates	gene	0.90
TNF-Α	activates	gene	0.90
INFLAMMATION	regulates	gene	0.90
AMPK	associated_with	entity	0.82
APOE	associated_with	gene	0.82
burn serum	activates	drug	0.80
hypoxia	activates	phenotype	0.80
JNK signaling pathway	regulates	pathway	0.80
ALS	associated_with	disease	0.80
PRKCD	associated_with	gene	0.80
FOS	activates	gene	0.80
FERROPTOSIS	inhibits	gene	0.80
ERK1	activates	gene	0.80
CYTOKINES	activates	gene	0.80
TNF	associated_with	gene	0.80
APOPTOSIS	therapeutic_target	gene	0.80
OXIDATIVE STRESS	inhibits	gene	0.80
ALZHEIMER	regulates	gene	0.80
GFAP	activates	gene	0.80
NF-ΚB	activates	gene	0.80
CANCER	associated_with	gene	0.80
PI3K	activates	gene	0.80
NEURODEGENERATION	regulates	gene	0.80
CANCER	activates	gene	0.80
HO-1	activates	gene	0.80

Targeting Hypotheses (6)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Astroglial Gap Junction Coordination via Connexin-43 Phospho	0.720	neurodegeneration	Perivascular spaces and glymphatic clear
The most realistic translational use of physiological SCFAs	0.610	neurodegeneration	Do physiological concentrations of SCFAs
MALAT1 Three-Way Junction as a Druggable Target for Structur	0.587	molecular biology	What are the conserved secondary structu
ER Stress Reduction as Adjunctive Therapy to Support Autopha	0.566	neurodegeneration	Why does iron chelation therapy worsen o
C1q-Alectinib Complexation Disrupts Tight Junction Integrity	0.455	molecular biology	Does Alectinib truly bind C1q directly w

Gap Junction Hemichannel Modulation for Controlled Mitochond	0.436	neurodegeneration	Mitochondrial transfer between neurons a

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (5)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Cx43 knockdown effects on mitochondrial transfer	exploratory	osteoarthritis	0.900	0.00	human bone marrow-derived MSCs	proposed	N/A
Leukocyte gene expression analysis in COVID-19 patients	exploratory	COVID-19	0.900	0.00	human leukocytes from COVID-19	proposed	N/A
Confocal imaging of MSC-chondrocyte interactions during mitochondrial	exploratory	osteoarthritis	0.850	0.00	human bone marrow-derived MSCs	proposed	N/A
Astrocyte Ferritin Iron Metabolism Dysfunction in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
Gap Junction Dysfunction Validation in Parkinson's Disease	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
PIEZO channels link mechanical forces to uterine contractions in parturition. [PMID:41231991]	Zhang Y, Kini SA, Mishkanian SA, Yarishk	Science	2025	1
GJA1-20k and Mitochondrial Dynamics. [PMID:35399255]	Shimura D, Shaw RM	Front Physiol	2022	1
Inhibition of connexin43 improves functional recovery after ischemic brain injur [PMID:25988944]	Li X, Zhao H, Tan X, Kostrzewa RM, Du G,	Glia	2015	1
Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline [PMID:41618855]	["Ying H", "Fan H", "Wang Y", "Jiang R",	Advanced science (Weinheim, Ba	2026	0
Prenatal lipopolysaccharide exposure programs cardiac fibrosis via dysregulating [PMID:41789580]	Wen Y, Yuan Y, Zhang H, Liu Y	Molecular medicine reports	2026	0
Metabolites released from apoptotic cells in central nervous system orchestrates [PMID:41518198]	Xiao F, Tan X, He A, Zhou Y, Xu K et al.	Autophagy	2026	0
The relationship between Connexin 43 (Cx43) and partner protein, human discs lar [PMID:41703342]	["Scott H", "Dong L", "Stevenson A", "Ma	Cell and tissue research	2026	0
Thermal Adaptation Inhibits the Wnt Signaling Pathway Regulating Autophagy and I [PMID:41889212]	["Song R", "Zhang Z", "Zhu S", "Fu K", "	Molecular reproduction and dev	2026	0
Identification and validation of ferroptosis-related genes for diabetic nephropa [PMID:41825713]	Duan H, Wang Y, Wang Q, Yan J, Fan X, Wu	European journal of pharmacolo	2026	0
Danggui Sini decoction attenuates intervertebral disc degeneration by regulating [PMID:41812505]	Chen S, Zhou X, Wang W, Zheng Y, Kang R,	International immunopharmacolo	2026	0
Reproductive tissue-derived stromal cells rescue fertility by coupling follicula [PMID:41888633]	["Borutinskait\u0117 V", "Krastinait\u01	Stem cells translational medic	2026	0
A Single-Cell Transcriptomic Atlas Elucidates a Microglial Gene Signature Linkin [PMID:41884157]	["Zhong R", "Yang H", "Li X", "Wang F",	Journal of inflammation resear	2026	0
Essential Role of CD63 in Maintaining Corneal Epithelial Identity in the Human L [PMID:41817143]	["Sasamoto Y", "Suzuki K", "Sato S", "Le	Investigative ophthalmology &	2026	0
Hypoxia Increases Connexin46 and Connexin43 Levels in KNS-42 Glioblastoma Cells. [PMID:41898710]	Minogue PJ, Beyer EC, Berthoud VM	International journal of molec	2026	0
Cx43 modulates malignant phenotypes in bladder cancer cells via the c-Src/PTEN/F [PMID:41910821]	["Chi Q", "Xu H", "Li H", "Ma G", "Li X"	Journal of molecular histology	2026	0
SnRNA-seq reveals the ameliorative effects of optimized Xueyu Jingshen formula o [PMID:41720010]	Bai J, Xie N, Hou Y, Yan J, Chen M, Yu S	Phytomedicine : international	2026	0
Transcriptome and alternative splicing analyses uncover immune-centric pathogene [PMID:41911957]	["Yan W", "Na L", "Tao G", "Jing L", "Yi	Gene	2026	0
Connexin and Pannexin Hemichannels: Broad-Spectrum Players in Neuroinflammatory [PMID:40956013]	["S\u00e1ez J", "Ocaranza F", "Prieto-Vi	Journal of neurochemistry	2025	0
Overlap in synaptic neurological condition susceptibility pathways and the neura [PMID:37807670]	["Frederiksen S", "Wicki-Stordeur L", "S	Channels (Austin, Tex.)	2023	0
Harlequin syndrome associated with thoracic epidural anaesthesia. [PMID:35118419]	Persson RM, Tellnes K, Hoven H, Haaverst	Anaesthesia reports	2022	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning JUN in their description or question text

Gap Junction Hemichannel Modulation for Controlled Mitochondrial Exchange

Score: 0.436 · neurodegeneration · 2026-04-02

Selective opening of pannexin-1 hemichannels creates controlled conduits for small mitochondria and mitochondrial compon

JUN