gene 689 words KG: JUN
Contents

JUN Gene

🧬 Gene Info
Gene SymbolJUN
Full NameJun Proto-Oncogene, AP-1 Transcription Factor Subunit
Chromosome1p32.1
Protein TypeTranscription Factor
Functionc-Jun/AP-1 is a key transcription factor
Primary Expressionproliferating neural progenitors and migrating neurons, declining to lower basal levels in the adult brain
PathwaysAkt, Amyloid, Apoptosis, Autophagy, Blood-Brain Barrier
UniProt IDP45985
NCBI Gene ID3715
Ensembl IDENSG00000100994
OMIM165160
GeneCardsJUN
Human Protein AtlasJUN
Associated DiseasesAddiction, Aging, Als, Alzheimer, Alzheimer's disease
Known Drugs/Compoundsanti-CD3, burn serum, pokeweed mitogen, quercetin
InteractionsABCA1, ABCB1, ACSL5, ACTB, Actin, AGING
KG Connections2425 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (59)

Piezoelectric Nanochannel BBB Disruption
Score: 0.52
Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro
Score: 0.61
Circadian-Gated Maresin Biosynthesis Amplification
Score: 0.56
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.82
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Circadian Clock-Autophagy Synchronization
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
Transcriptional Autophagy-Lysosome Coupling
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
Aquaporin-4 Polarization Rescue
Score: 0.73
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Phase-Separated Organelle Targeting
Score: 0.73
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
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Related Analyses (10)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived

Related Experiments (1)

Network pharmacology analysis of QTJD active compounds and p
exploratory · proposed · Score: 0.90

See Also (7)

ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: activates
ABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member
gene · KG edge: activates
ACTB Gene
gene · KG edge: activates
ADCY9 Gene
gene · KG edge: regulates
ADRA1D Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

JUN contributes_to AP1
JUN therapeutic_target SLC16A2
JUN protects_against APOE
JUN protects_against RELN
JUN regulates DAB1
JUN regulates FYN
JUN regulates SRC
JUN inhibits HCN1
JUN inhibits HCN4
JUN inhibits HCN2

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