| Gene Symbol | JUN |
| Full Name | Jun Proto-Oncogene, AP-1 Transcription Factor Subunit |
| Chromosome | 1p32.1 |
| Protein Type | Transcription Factor |
| Function | c-Jun/AP-1 is a key transcription factor |
| Primary Expression | proliferating neural progenitors and migrating neurons, declining to lower basal levels in the adult brain |
| Pathways | Akt, Amyloid, Apoptosis, Autophagy, Blood-Brain Barrier |
| UniProt ID | P45985 |
| NCBI Gene ID | 3715 |
| Ensembl ID | ENSG00000100994 |
| OMIM | 165160 |
| GeneCards | JUN |
| Human Protein Atlas | JUN |
| DNA Binding | Forms homodimers or heterodimers to bind the TRE (12-O-tetradecanoylphorbol-13-acetate response element) DNA sequence |
| Transcriptional Activation | Recruits coactivators (CBP/p300) to activate target gene transcription |
| Associated Diseases | Addiction, Aging, Als, Alzheimer, Autoimmune |
| Known Drugs/Compounds | anti-CD3, burn serum, pokeweed mitogen, quercetin |
| Interactions | ABCA1, ABCB1, ACSL5, ACTB, Actin, AGING |
| KG Connections | 2436 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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