gene

WNT5A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about WNT5A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

19Connections

0Hypotheses

0Analyses

11Outgoing

8Incoming

0Experiments

0Debates

Summary

Page for WNT5A Gene

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🧬 Gene Info

Gene Symbol	WNT5A
Full Name	Wnt Family Member 5A
Chromosome	3p14.3
Function	WNT5A encodes a member of the Wnt family of secreted signaling molecules that play critical roles in embryonic development, cell polarity, migration, and tissue patterning.
Primary Expression	the cortical marginal zone, intermediate zone, and subventricular zone, regulating neuronal migration
Molecular Weight	40 kDa
Amino Acids	380 aa
Pathways	wnt, WNT, Wnt, wNT, Wnt Signaling
UniProt ID	Q9H0J5
Ensembl ID	ENSG00000114270
GeneCards	WNT5A
Human Protein Atlas	WNT5A
High expression	Cerebral cortex, hippocampus (CA regions), cerebellum (Purkinje cells)
Associated Diseases	Alzheimer's disease, Parkinson's disease, ALS
Interactions	ALZHEIMER, ALZHEIMER'S DISEASE, AND, DEMENTIA, INFLAMMATION, KRAS
KG Connections	19 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: WNT5A — AlphaFold Q9H0J5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

WNT5A Gene

gene · 564 words

→

WNT5A Protein

protein · 600 words

→

Pathway Diagram

graph TD
    WNT5A["WNT5A"]
    Dementia{"Dementia"}
    WNT5A -->|"activates"| Dementia
    Alzheimer{"Alzheimer"}
    WNT5A -->|"activates"| Alzheimer
    Inflammation{"Inflammation"}
    WNT5A -->|"activates"| Inflammation
    Ms{"Ms"}
    WNT5A -->|"activates"| Ms
    Als{"Als"}
    WNT5A -->|"activates"| Als
    TAU["TAU"]
    WNT5A -->|"activates"| TAU
    INFLAMMATION["INFLAMMATION"]
    WNT5A -->|"activates"| INFLAMMATION
    Oxidative_Stress(["Oxidative Stress"])
    WNT5A -->|"activates"| Oxidative_Stress
    Wnt(["Wnt"])
    WNT5A -->|"activates"| Wnt
    Long_Term_Potentiation(["Long-Term Potentiation"])
    WNT5A -->|"activates"| Long_Term_Potentiation
    Tau_Phosphorylation(["Tau Phosphorylation"])
    WNT5A -->|"activates"| Tau_Phosphorylation
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    OXIDATIVE_STRESS -->|"activates"| WNT5A
    KRAS["KRAS"]
    KRAS -->|"activates"| WNT5A
    WNT["WNT"]
    WNT -->|"activates"| WNT5A
    DEMENTIA["DEMENTIA"]
    DEMENTIA -->|"activates"| WNT5A

Outgoing (11)

Target	Relation	Type	Str
Als	activates	disease	0.65
Dementia	activates	disease	0.65
Alzheimer	activates	disease	0.65
Inflammation	activates	disease	0.65
Ms	activates	disease	0.65
TAU	activates	gene	0.60
Tau Phosphorylation	activates	pathway	0.60
INFLAMMATION	activates	gene	0.60
Oxidative Stress	activates	pathway	0.60
Wnt	activates	pathway	0.60
Long-Term Potentiation	activates	pathway	0.60

Incoming (8)

Source	Relation	Type	Str
WNT3A	expressed_in	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
KRAS	activates	gene	0.60
WNT	activates	gene	0.60
DEMENTIA	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
AND	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning WNT5A in their description or question text

No additional research found