gene

TAC1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TAC1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

27Connections

0Hypotheses

0Analyses

16Outgoing

11Incoming

0Experiments

0Debates

Summary

TAC1 encodes tachykinin precursors including substance P and neurokinin A, involved in pain transmission, neuroinflammation, and neurodegenerative disease pathogenesis

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🧬 Gene Info

Gene Symbol	TAC1
Chromosome	7q21
Primary Expression	Thalamus, Hypothalamus
Amino Acids	381 aa
Exons	7
Pathways	NF-κB
Ensembl ID	ENSG00000125037
GeneCards	TAC1
Human Protein Atlas	TAC1
Type A preprotachykinin	Contains substance P and neurokinin A
Type B preprotachykinin	Encodes only neurokinin A
Type C preprotachykinin	Contains non-tachykinin sequence
Substantia nigra	Moderate expression in dopaminergic neurons[@yaus2012]
Striatum	High expression in medium spiny neurons
Hypothalamus	Strong expression in paraventricular nucleus
Associated Diseases	Alzheimer's disease, Parkinson's disease
Interactions	TRPM8, WNT3A
KG Connections	27 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

TAC1 Gene

gene · 901 words

→

TAC1 (Tachykinin Precursor 1) Protein

protein · 1709 words

→

Pathway Diagram

graph TD
    TAC1["TAC1"]
    Ms{"Ms"}
    TAC1 -->|"expressed in"| Ms
    Tumor{"Tumor"}
    TAC1 -->|"expressed in"| Tumor
    IMMUNE_INFILTRATION["IMMUNE INFILTRATION"]
    TAC1 -->|"expressed in"| IMMUNE_INFILTRATION
    CHONDROCYTE_APOPTOSIS["CHONDROCYTE APOPTOSIS"]
    TAC1 -->|"expressed in"| CHONDROCYTE_APOPTOSIS
    APOPTOSIS["APOPTOSIS"]
    TAC1 -->|"expressed in"| APOPTOSIS
    SPP1["SPP1"]
    TAC1 -->|"expressed in"| SPP1
    Apoptosis(["Apoptosis"])
    TAC1 -->|"expressed in"| Apoptosis
    neurodegeneration["neurodegeneration"]
    TAC1 -->|"implicated in"| neurodegeneration
    PLIN1["PLIN1"]
    PLIN1 -->|"expressed in"| TAC1
    IGF1["IGF1"]
    IGF1 -->|"expressed in"| TAC1
    P2RY14["P2RY14"]
    P2RY14 -->|"expressed in"| TAC1
    MMP9["MMP9"]
    MMP9 -->|"expressed in"| TAC1
    FOS["FOS"]
    FOS -->|"expressed in"| TAC1
    style TAC1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (16)

Target	Relation	Type	Str
Azole Resistance	contributes_to	mechanism	0.80
Ms	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
CHONDROCYTE APOPTOSIS	expressed_in	gene	0.60
IMMUNE INFILTRATION	expressed_in	gene	0.60
TRPM8	activates	gene	0.60
WNT3A	activates	gene	0.60
SPP1	expressed_in	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
Apoptosis	expressed_in	pathway	0.60
FOXP1	biomarker_for	gene	0.60
AVP	biomarker_for	gene	0.60
Hypothalamus	expressed_in	brain_region	0.55
Thalamus	expressed_in	brain_region	0.55
Neuron	expressed_in	cell_type	0.55
FOXP1	associated_with	gene	0.50

Incoming (11)

Source	Relation	Type	Str
BDNF	upregulates	protein	0.90
IGF1	expressed_in	gene	0.60
P2RY14	expressed_in	gene	0.60
PLIN1	expressed_in	gene	0.60
FOS	expressed_in	gene	0.60
MMP9	expressed_in	gene	0.60
RNA	regulates	gene	0.60
AND	biomarker_for	gene	0.60
CRH	biomarker_for	gene	0.60
NR3C1	biomarker_for	gene	0.60
NR3C1	associated_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TAC1 in their description or question text

No additional research found