gene

ROCK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ROCK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

104Connections

0Hypotheses

0Analyses

50Outgoing

35Incoming

0Experiments

0Debates

Summary

ROCK1 (Rho Associated Coiled-Coil Containing Protein Kinase 1) - serine/threonine kinase effector of Rho GTPases regulating cytoskeleton, cell adhesion, and synaptic plasticity. Implicated in AD, PD, ALS, and stroke.

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🧬 Gene Info

Gene Symbol	ROCK1
Full Name	Rho Associated Coiled-Coil Containing Protein Kinase 1
Chromosome	18q11.1
Protein Type	Serine/Threonine Kinase
Function	ROCK1 encodes a serine/threonine kinase that is a major effector of Rho GTPases.
Primary Expression	human tissues, with particularly high expression in the brain, where it regulates cytoskeletal dynamics essential for neuronal function and connectivi
Molecular Weight	158 kDa
Amino Acids	354 aa
Pathways	Akt, Apoptosis, Autophagy, Mtor, Oxidative Stress
UniProt ID	[Q13464](https://www.uniprot.org/uniprot/Q13464)
Ensembl ID	ENSG00000067900
OMIM	601703
GeneCards	ROCK1
Human Protein Atlas	ROCK1
N-terminal kinase domain	Catalytic serine/threonine kinase activity (~300 aa)
Associated Diseases	ALS, Alzheimer, neurodegeneration
Interactions	AKT, AND, APOPTOSIS, APP, APP/PS1, AUTOPHAGY
KG Connections	104 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

ROCK1 Gene

gene · 3220 words

→

ROCK1 Protein

protein · 583 words

→

Pathway Diagram

graph TD
    ROCK1["ROCK1"]
    TFEB["TFEB"]
    ROCK1 -->|"phosphorylates"| TFEB
    P62["P62"]
    ROCK1 -->|"co-localizes"| P62
    PRKCH["PRKCH"]
    ROCK1 -->|"regulates"| PRKCH
    Alzheimer{"Alzheimer"}
    ROCK1 -->|"regulates"| Alzheimer
    Neurodegeneration{"Neurodegeneration"}
    ROCK1 -->|"regulates"| Neurodegeneration
    Ms{"Ms"}
    ROCK1 -->|"regulates"| Ms
    Als{"Als"}
    ROCK1 -->|"activates"| Als
    Cancer{"Cancer"}
    ROCK1 -->|"activates"| Cancer
    Inflammation{"Inflammation"}
    ROCK1 -->|"activates"| Inflammation
    LAMP1["LAMP1"]
    ROCK1 -->|"expressed in"| LAMP1
    SQSTM1["SQSTM1"]
    ROCK1 -->|"expressed in"| SQSTM1
    RHOA["RHOA"]
    ROCK1 -->|"activates"| RHOA
    SQSTM1 -->|"co-localizes"| ROCK1
    APP_PS1["APP/PS1"]
    APP_PS1 -->|"inhibits"| ROCK1
    P62 -->|"expressed in"| ROCK1
    MICROGLIA["MICROGLIA"]
    MICROGLIA -->|"associated with"| ROCK1
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"regulates"| ROCK1
    LYSOSOMAL_BIOGENESIS["LYSOSOMAL BIOGENESIS"]
    LYSOSOMAL_BIOGENESIS -->|"regulates"| ROCK1
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"regulates"| ROCK1
    LAMP1 -->|"expressed in"| ROCK1
    RHOA -->|"activates"| ROCK1
    APP["APP"]
    APP -->|"inhibits"| ROCK1
    SQSTM1 -->|"expressed in"| ROCK1
    TFEB -->|"regulates"| ROCK1
    style ROCK1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (69)

Target	Relation	Type	Str
P62	co-localizes	gene	0.90
TFEB	phosphorylates	gene	0.90
PRKCH	regulates	gene	0.80
Alzheimer	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Ms	regulates	disease	0.65
Als	activates	disease	0.65
Inflammation	activates	disease	0.65
Nephropathy	activates	disease	0.65
Cancer	activates	disease	0.65
Fibrosis	inhibits	disease	0.65
Traumatic Brain Injury	activates	disease	0.65
Stroke	activates	disease	0.65
Als	inhibits	disease	0.65
NEURON	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
MICROGLIA	activates	gene	0.60
ROS	activates	gene	0.60
STROKE	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
APP	inhibits	gene	0.60
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
Oxidative Stress	activates	pathway	0.60
Mtor	activates	pathway	0.60
Apoptosis	activates	pathway	0.60
Akt	activates	pathway	0.60
EXOSOMES	activates	gene	0.60
Wnt	inhibits	pathway	0.60
LAMP1	expressed_in	gene	0.60
SQSTM1	expressed_in	gene	0.60
RHOA	activates	gene	0.60
TFEB	regulates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
BRAIN INJURY	activates	gene	0.60
AND	activates	gene	0.60
T Cell	associated_with	cell_type	0.60
Ras	inhibits	protein	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
LYSOSOME	inhibits	gene	0.60
Autophagy	activates	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
ROCK2	activates	gene	0.60
PTEN	activates	gene	0.60
MTOR	activates	gene	0.60
AKT	activates	gene	0.60
Rb	inhibits	protein	0.60
Gsk-3	associated_with	protein	0.60
neurodegeneration	associated_with	disease	0.60
ALZHEIMER	regulates	gene	0.60
MICROGLIA	associated_with	gene	0.60

Incoming (35)

Source	Relation	Type	Str
SQSTM1	co-localizes	gene	0.90
MICROGLIA	associated_with	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
LYSOSOMAL BIOGENESIS	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
P62	expressed_in	gene	0.60
DRP1	activates	gene	0.60
P62	associated_with	gene	0.60
SOX2	activates	gene	0.60
APP/PS1	inhibits	gene	0.60
HDAC3	activates	gene	0.60
FOXO1	associated_with	gene	0.60
FOXO1	activates	gene	0.60
ROCK	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
RHOA	inhibits	gene	0.60
PTEN	activates	gene	0.60
LYSOSOME	inhibits	gene	0.60
ALZHEIMER	regulates	gene	0.60
AND	regulates	gene	0.60
CANCER	activates	gene	0.60
LAMP1	expressed_in	gene	0.60
RHOA	activates	gene	0.60
APP	inhibits	gene	0.60
SQSTM1	expressed_in	gene	0.60
TFEB	regulates	gene	0.60
CFTR	activates	gene	0.60
AKT	activates	gene	0.60
CD55	activates	gene	0.55
CFH	activates	gene	0.55
LIMK1	activates	gene	0.55
RNA	activates	gene	0.55
FOXO1	co_expressed_with	gene	0.50
HDAC3	co_expressed_with	gene	0.50
MTOR	regulates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ROCK1 in their description or question text

No additional research found