concept

TRPML1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TRPML1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

197Connections

4Hypotheses

1Analyses

50Outgoing

50Incoming

1Experiments

2Debates

No summary available yet.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	TRPML1
Key Genes/Proteins	AKT, AMPK, AND, APOE, App, ATG12
Related Diseases	Als, ALS, Alzheimer's disease
Linked Hypotheses	4 hypotheses

Wiki Pages (2)

Knowledge base pages for this entity

MCOLN1 — Mucolipin-1 (TRPML1)

gene · 817 words

→

Mucolipin-1 (TRPML1) Protein

protein · 660 words

→

Pathway Diagram

graph TD
    TRPML1["TRPML1"]
    TRPML1 -->|"expressed in"| Lysosome["Lysosome"]
    TRPML1 -->|"regulates"| Autophagy["Autophagy"]
    TRPML1 -->|"causes"| Mucolipidosis_Type_IV["Mucolipidosis Type IV"]
    TRPML1 -->|"regulates"| Calcium_Dynamics["Calcium Dynamics"]
    TRPML1 -->|"activates"| TFEB["TFEB"]
    TRPML1 -.prevents.-> mitochondrial_fragmentation["mitochondrial fragmentation"]
    TRPML1 -->|"mediates"| Lysosomal_Calcium_Signaling["Lysosomal Calcium Signaling"]
    TRPML1 -->|"involved_in"| Vesicular_Trafficking["Vesicular Trafficking"]
    MCOLN1["MCOLN1"] -->|"encodes"| TRPML1
    TRPML2["TRPML2"] -->|"co_expressed_with"| TRPML1
    TRPML3["TRPML3"] -->|"co_expressed_with"| TRPML1
    LYSOSOME["LYSOSOME"] -->|"regulates"| TRPML1
    AND["AND"] -->|"regulates"| TRPML1
    NEURODEGENERATION["NEURODEGENERATION"] -->|"causes"| TRPML1

Outgoing (101)

Target	Relation	Type	Str
h-5cbf67bf98	targeted_by	hypothesis	1.00
h-3cdc8defe3	targeted_by	hypothesis	1.00
Lysosome	expressed_in	cell_type	1.00
Mucolipidosis Type IV	associated_with	disease	1.00
Mitochondrial Calcium Dynamics	regulates	process	0.95
Calcium Dynamics	regulates	process	0.95
Autophagy	regulates	process	0.95
Mucolipidosis Type IV	causes	disease	0.95
Mucolipidosis IV	associated_with	disease	0.95
Lysosomal Calcium Release	mediates	process	0.95
TFEB	activates	protein	0.95
mitochondrial fragmentation	prevents	phenotype	0.92
Vesicular Trafficking	involved_in	process	0.90
calcium	mediates	compound	0.90
Calcium Homeostasis	regulates	process	0.90
Mucolipidosis Type Iv	causes	disease	0.90
lysosomal trafficking	regulates	process	0.90
Late Endolysosomal Compartment Enlargement	involved_in	phenotype	0.90
Lysosomal Calcium Signaling	mediates	process	0.90
Mitophagy	regulates	process	0.90
Autophagy	associated_with	process	0.90
Ion Homeostasis	regulates	process	0.85
Lipid Homeostasis	regulates	process	0.85
Mucolipidosis Type Iv	therapeutic_target	disease	0.85
Ion Homeostasis	involved_in	process	0.85
Lipid Homeostasis	involved_in	process	0.85
Lysosomal Storage Disorders	associated_with	disease	0.85
Cargo Degradation	involved_in	process	0.80
Mitochondrial Homeostasis	involved_in	process	0.80
vesicular trafficking	regulates	process	0.80
cellular homeostasis	contributes_to	process	0.80
Cellular Adaptation To Nutrient Availability	involved_in	process	0.75
autophagy pathway	participates_in	pathway	0.70
Cancer	regulates	disease	0.65
Tumor	regulates	disease	0.65
Als	regulates	disease	0.65
Ferroptosis	therapeutic_target	disease	0.65
ALS	regulates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Neurodegeneration	causes	disease	0.65
Neurodegeneration	activates	disease	0.65
Cancer	activates	disease	0.65
GENES	expressed_in	gene	0.60
TRPML2	expressed_in	gene	0.60
MITOCHONDRIA	regulates	gene	0.60
AND	activates	gene	0.60
ROS	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
TRPML2	associated_with	gene	0.60
ATG8	activates	gene	0.60

Incoming (96)

Source	Relation	Type	Str
h-3cdc8defe3	targets	hypothesis	1.00
h-5cbf67bf98	targets	hypothesis	1.00
MCOLN1	encodes	gene	1.00
31112550	mediates	paper	0.90
Artemisia argyi	activates	drug	0.90
TRPML3	interacts_with	protein	0.80
TRPML2	interacts_with	protein	0.80
FERROPTOSIS	therapeutic_target	gene	0.60
ATG16L1	activates	gene	0.60
MITOCHONDRIA	regulates	gene	0.60
JUN	regulates	gene	0.60
SNARE	activates	gene	0.60
AMPK	activates	gene	0.60
ATG5	activates	gene	0.60
ATM	activates	gene	0.60
ATR	activates	gene	0.60
CASP3	activates	gene	0.60
CTSB	activates	gene	0.60
CTSD	activates	gene	0.60
DYNLL1	activates	gene	0.60
EIF4EBP1	activates	gene	0.60
GLUT4	activates	gene	0.60
HOMER1	activates	gene	0.60
JNK1	activates	gene	0.60
LC3B	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
MAP2	activates	gene	0.60
MAPK14	activates	gene	0.60
MAPK8	activates	gene	0.60
RILP	activates	gene	0.60
SLC2A4	activates	gene	0.60
APOE	activates	gene	0.60
JIP4	activates	gene	0.60
metformin	targets	drug	0.60
ATG12	activates	gene	0.60
GAPDH	activates	gene	0.60
LAMP1	activates	gene	0.60
MAP1LC3	activates	gene	0.60
MCOLN1	activates	gene	0.60
MTORC1	activates	gene	0.60
NSF	activates	gene	0.60
RNA	activates	gene	0.60
SQSTM1	activates	gene	0.60
STX17	activates	gene	0.60
rapamycin	targets	drug	0.60
MCOLN1	associated_with	gene	0.60
TRPML2	expressed_in	gene	0.60
CANCER	activates	gene	0.60
ROS	activates	gene	0.60
MCOLN1	targets	gene	0.60

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Spatiotemporal coupling between TRPML1-mediated lysosomal ca	0.705	neurodegeneration	What determines the specificity of calci
PIKFYVE Inhibition Activates Aggregate Exocytosis via PI(3,5	0.584	neurodegeneration	How does PIKFYVE inhibition activate unc
Sequential TRPML1 Activation Following Autophagy Priming	0.575	neurodegeneration	Does TRPML1 enhancement cause therapeuti
TRPML1-PINK1/Parkin Axis Coordinates Mitophagy with Lysosoma	0.560	neurodegeneration	Does TRPML1 enhancement cause therapeuti

Mentioning Analyses (1)

Scientific analyses that reference this entity

Does TRPML1 enhancement cause therapeutic benefit or paradoxical lysosomal dysfu

neurodegeneration | 2026-04-16 | 2 hypotheses Top: 0.575

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
PPP3/calcineurin-dependent TFEB dephosphorylation mechanism	exploratory	motoneuron degeneration	0.800	0.00	neuronal cell lines	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

The debate revealed conflicting evidence about whether TRPML1 activation rescues

closed · Rounds: 4 · Score: 0.72 · 2026-04-21

The debate revealed conflicting evidence about whether TRPML1 activation rescues

closed · Rounds: 4 · Score: 0.46 · 2026-04-16

Related Research

Hypotheses and analyses mentioning TRPML1 in their description or question text

No additional research found