Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about JIP4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | JIP4 |
| Key Genes/Proteins | AMPK, LRRK2, RAB10, RAB12, TMEM55B, TRPML1 |
| Related Pathways | autophagy pathway, NF-kB signaling |
| Linked Hypotheses | 2 hypotheses |
graph TD
JIP4[JIP4]
JIP4 -->|inhibits| TMEM55B[TMEM55B]
JIP4 -->|activates| LRRK2[LRRK2]
JIP4 -->|interacts| RAB10[RAB10]
JIP4 -->|interacts| RAB12[RAB12]
JIP4 -->|interacts| WDR81[WDR81]
JIP4 -->|activates| TRPML1[TRPML1]
AMPK[AMPK] -->|activates| JIP4
metformin[metformin] -->|targets| JIP4
benchmark_ot_ad_answer_key_JIP[benchmark_ot_ad_answer_key:JIP4] -->|data_in| JIP4| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:JIP4 | data_in | dataset_row | 0.00 |
| TMEM55B | inhibits | gene | 0.70 |
| RAB10 | interacts_with | gene | 0.60 |
| RAB12 | interacts_with | gene | 0.60 |
| RAB10 | activates | gene | 0.60 |
| RAB12 | activates | gene | 0.60 |
| LRRK2 | activates | gene | 0.60 |
| WDR81 | interacts_with | gene | 0.60 |
| TRPML1 | activates | gene | 0.60 |
| NF-kB signaling | participates_in | pathway | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| TMEM55B | interacts_with | gene | 0.60 |
| LRRK2 | interacts_with | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:JIP4 | data_in | dataset_row | 0.00 |
| 33177079 | is identified as partner of | paper | 0.90 |
| 33177079 | promotes formation of | paper | 0.90 |
| 33177079 | is LRRK2 partner at | paper | 0.90 |
| 33177079 | promotes the formation of | paper | 0.90 |
| 33177079 | is identified as | paper | 0.90 |
| AMPK | activates | gene | 0.60 |
| metformin | targets | drug | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| A downstream LRRK2-Rab10-JIP4 lysosomal stress loop promotes | 0.680 | neurodegeneration | Do pathogenic LRRK2 mutations amplify vo |
| LYTL and JIP4-dependent lysosomal remodeling may show mutant | 0.580 | neurodegeneration | Do pathogenic LRRK2 mutations amplify vo |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Longitudinal dietary change analysis and ADRD risk over 10 years | clinical | Alzheimer's disease and relate | 0.930 | 0.00 | human patients | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning JIP4 in their description or question text
No additional research found