gene

ELAVL3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ELAVL3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

63Connections

0Hypotheses

0Analyses

41Outgoing

22Incoming

0Experiments

0Debates

Summary

ELAVL3 is a gene implicated in neurodegeneration research. Key relationships include: activates, inhibits, regulates. Associated with ALS, Als, Inflammation. Connected to 46 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ELAVL3
Function	ELAVL3 is a 367 amino acid protein characterized by its neuron-specific expression pattern and its critical functions in post-transcriptional gene regulation
Primary Expression	Spinal Cord
Molecular Weight	39 kDa
Amino Acids	367 aa
Pathways	Oxidative Stress, Apoptosis, Autophagy
GeneCards	ELAVL3
Human Protein Atlas	ELAVL3
Associated Diseases	neurodegeneration
Interactions	ACHE, APOPTOSIS, AUTOPHAGY, AXON, BPMC, Caspase
KG Connections	63 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

ELAVL3 Gene

gene · 1251 words

→

ELAVL3 Protein

protein · 871 words

→

Pathway Diagram

graph TD
    ELAVL3["ELAVL3"]
    TREM2["TREM2"]
    ELAVL3 -->|"upregulates"| TREM2
    neurodegeneration["neurodegeneration"]
    ELAVL3 -->|"associated with"| neurodegeneration
    Als{"Als"}
    ELAVL3 -->|"activates"| Als
    Ms{"Ms"}
    ELAVL3 -->|"activates"| Ms
    Inflammation{"Inflammation"}
    ELAVL3 -->|"activates"| Inflammation
    ALS{"ALS"}
    ELAVL3 -->|"activates"| ALS
    MANF["MANF"]
    ELAVL3 -->|"inhibits"| MANF
    MBP["MBP"]
    ELAVL3 -->|"inhibits"| MBP
    Oxidative_Stress(["Oxidative Stress"])
    ELAVL3 -->|"activates"| Oxidative_Stress
    Apoptosis(["Apoptosis"])
    ELAVL3 -->|"activates"| Apoptosis
    GFAP["GFAP"]
    ELAVL3 -->|"inhibits"| GFAP
    GAP43["GAP43"]
    ELAVL3 -->|"inhibits"| GAP43
    GFAP -->|"inhibits"| ELAVL3
    GAP43 -->|"inhibits"| ELAVL3
    MBP -->|"inhibits"| ELAVL3
    GENES["GENES"]
    GENES -->|"inhibits"| ELAVL3
    MANF -->|"inhibits"| ELAVL3
    ACHE["ACHE"]
    ACHE -->|"activates"| ELAVL3
    ROS["ROS"]
    ROS -->|"activates"| ELAVL3
    AXON["AXON"]
    AXON -->|"activates"| ELAVL3
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"activates"| ELAVL3
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    OXIDATIVE_STRESS -->|"activates"| ELAVL3
    TUBULIN["TUBULIN"]
    TUBULIN -->|"inhibits"| ELAVL3
    NEURON["NEURON"]
    NEURON -->|"activates"| ELAVL3
    style ELAVL3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (41)

Target	Relation	Type	Str
TREM2	upregulates	gene	0.80
Neurodegeneration	activates	disease	0.65
Parkinson	regulates	disease	0.65
Als	activates	disease	0.65
Ms	activates	disease	0.65
Inflammation	activates	disease	0.65
ALS	activates	disease	0.65
Tubulin	inhibits	protein	0.60
MYELIN	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
NEUROTOXICITY	activates	gene	0.60
Oxidative Stress	activates	pathway	0.60
Apoptosis	activates	pathway	0.60
GFAP	inhibits	gene	0.60
GAP43	regulates	entity	0.60
GFAP	regulates	entity	0.60
MANF	regulates	entity	0.60
MBP	regulates	entity	0.60
TUBULIN	regulates	entity	0.60
NEURON	activates	gene	0.60
Neutrophil	activates	cell_type	0.60
Caspase	activates	protein	0.60
MANF	inhibits	gene	0.60
MBP	inhibits	gene	0.60
Rb	activates	protein	0.60
Autophagy	activates	pathway	0.60
Neuron	activates	cell_type	0.60
GENES	inhibits	gene	0.60
BPMC	inhibits	gene	0.60
SYN2A	inhibits	gene	0.60
Raf	activates	protein	0.60
GAP43	inhibits	gene	0.60
MAP1LC3B	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
ROS	activates	gene	0.60
AXON	activates	gene	0.60
ACHE	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
Neuron	expressed_in	cell_type	0.55
Spinal Cord	expressed_in	brain_region	0.55
TUBULIN	inhibits	protein	0.50

Incoming (22)

Source	Relation	Type	Str
Bpmc	downregulates	compound	0.85
TUBULIN	inhibits	gene	0.60
MBP	inhibits	gene	0.60
MANF	inhibits	gene	0.60
NEUROTOXICITY	activates	gene	0.60
MYELIN	activates	gene	0.60
BPMC	inhibits	gene	0.60
GENES	inhibits	gene	0.60
ACHE	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
PARKINSON	regulates	gene	0.60
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
AUTOPHAGY	activates	gene	0.60
SYN2A	inhibits	gene	0.60
INFLAMMATION	activates	gene	0.60
GFAP	inhibits	gene	0.60
GAP43	inhibits	gene	0.60
ROS	activates	gene	0.60
AXON	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
NEURON	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ELAVL3 in their description or question text

No additional research found