gene 1,184 words KG: TIMM22
Contents

TIMM22 Gene - Translocase of Inner Mitochondrial Membrane 22

🧬 Gene Info
Gene SymbolTIMM22
Chromosome17p13.2
Protein FamilyTranslocase of inner mitochondrial membrane (TIM) family
Functionis an essential component of the TIM22 complex, which mediates the insertion of carrier proteins into the mitochondrial inner membrane.
Primary ExpressionMitochondrial inner membrane
Subcellular LocalizationMitochondrial inner membrane
Molecular Weight25 kDa
Amino Acids227 aa
UniProt IDQ9Y5J7
GeneCardsTIMM22
Human Protein AtlasTIMM22
Associated DiseasesParkinson's Disease, Mitochondrial Disorders
InteractionsBECN1, BNIP3, BNIP3L, CEBPB, DDIT3, DNM1L
KG Connections43 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (4)

TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Digital Twin-Guided Metabolic Reprogramming
Score: 0.55

Related Analyses (2)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (5)

Brain Connectivity-Targeted tACS Trial in Early AD
clinical · proposed · Score: 0.40
AAV-LRRK2 Gene Therapy IND-Enabling Study Design
clinical · proposed · Score: 0.40
Mechanism: Progranulin Loss and TDP-43 Pathology in FTD
validation · proposed · Score: 0.40
Synaptic Mitochondrial Resilience Enhancement for Parkinson'
validation · proposed · Score: 0.40
TDP-43 PET Ligand Development for FTD and ALS
clinical · proposed · Score: 0.40

See Also (15)

SIRT1 (Redirect)
redirect · KG edge: inhibits
SPG7 (Redirect)
redirect · KG edge: inhibits
mTOR Signaling Dysregulation in Progressive Supranuclea
event · KG edge: inhibits
BECN1 Gene
gene · KG edge: inhibits
BNIP3 Gene
gene · KG edge: inhibits

Knowledge Graph (12 edges)

BNIP3 inhibits TIMM22
VDAC1 inhibits TIMM22
FUNDC1 inhibits TIMM22
TOMM20 inhibits TIMM22
TIMM9 inhibits TIMM22
TIMM17B inhibits TIMM22
OMA1 inhibits TIMM22
TIMM23 inhibits TIMM22
MTOR inhibits TIMM22
NRF1 inhibits TIMM22

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